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Displaying results 1651 - 1660 of 10000 in total
  1. Target

    Muscarinic acetylcholine receptor M5

    go.drugbank.com/bio_entities/BE0000247
    TargetHumans

    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action

    Polypeptides: Muscarinic acetylcholine receptor M5Function: G protein-coupled acetylcholine receptor activity
  2. Target

    Alpha-2C adrenergic receptor

    go.drugbank.com/bio_entities/BE0000342
    TargetHumans

    Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (...

    Polypeptides: Alpha-2C adrenergic receptorSynonyms: Alpha-2 adrenergic receptor subtype C4
  3. Target

    5-hydroxytryptamine receptor 2B

    go.drugbank.com/bio_entities/BE0000393
    TargetHumans

    G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:18703043, PubMed:23519210, PubMed:7926008, PubMed:8078486, PubMed:8143856, PubMed:8882600). … Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538, PubMed

    Polypeptides: 5-hydroxytryptamine receptor 2BSynonyms: Serotonin receptor 2B
  4. Target

    Somatostatin receptor type 1

    go.drugbank.com/bio_entities/BE0000452
    TargetHumans

    Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

    Polypeptides: Somatostatin receptor type 1
  5. Target

    5-hydroxytryptamine receptor 1F

    go.drugbank.com/bio_entities/BE0000460
    TargetHumans

    Receptor for lasmiditan, a drug for the treatment of acute migraine (PubMed:34239069). … G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:21422162, PubMed:34239069, PubMed:8380639, PubMed:8384716).

    Polypeptides: 5-hydroxytryptamine receptor 1FSynonyms: Serotonin receptor 1F
  6. Target

    5-hydroxytryptamine receptor 1E

    go.drugbank.com/bio_entities/BE0000476
    TargetHumans

    G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:14744596, PubMed:1513320, PubMed:1608964, PubMed:1733778, PubMed:21422162, PubMed:33762731). … Also functions as a receptor for various alkaloids and psychoactive substances (PubMed:14744596, PubMed:1513320, PubMed:1608964, PubMed:1733778, PubMed:21422162, PubMed:33762731).

    Polypeptides: 5-hydroxytryptamine receptor 1ESynonyms: Serotonin receptor 1E
  7. Target

    Low-density lipoprotein receptor

    go.drugbank.com/bio_entities/BE0000499
    TargetCarrierHumans

    In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.

    Polypeptides: Low-density lipoprotein receptorSynonyms: LDL receptor
  8. Target

    Extracellular calcium-sensing receptor

    go.drugbank.com/bio_entities/BE0000509
    TargetHumans

    full receptor activation (PubMed:27386547, PubMed:27434672, PubMed:32817431, PubMed:33603117, PubMed:34194040). … G protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:17555508, PubMed:19789209, PubMed:21566075

    Polypeptides: Extracellular calcium-sensing receptorSynonyms: Parathyroid cell calcium-sensing receptor 1
  9. Target

    5-hydroxytryptamine receptor 2C

    go.drugbank.com/bio_entities/BE0000533
    TargetHumans

    G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:12970106, PubMed:18703043, PubMed:19057895, PubMed:29398112, PubMed:7895773). … Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD)

    Polypeptides: 5-hydroxytryptamine receptor 2CSynonyms: Serotonin receptor 2C, 5-hydroxytryptamine receptor 1C
  10. Target

    Alpha-1B adrenergic receptor

    go.drugbank.com/bio_entities/BE0000575
    TargetHumans

    Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenge...

    Polypeptides: Alpha-1B adrenergic receptorFunction: alpha1-adrenergic receptor activity