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Displaying results 161 - 170 of 135483 in total
  1. Pathway

    Esmolol Action Pathway (New)

    smpdb.ca/view/SMP0126202
    Drug action

    It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. … cAMP, PKA, SRC and nitric oxide synthase signaling.

    Drugs: ATP · Esmolol · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  2. Pathway

    Oxprenolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126219
    Drug action

    It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. … cAMP, PKA, SRC and nitric oxide synthase signaling.

    Drugs: ATP · Calcium · Oxprenolol
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  3. Pathway

    Penbutolol Action Pathway (New)

    smpdb.ca/view/SMP0126220
    Drug action

    It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. … cAMP, PKA, SRC and nitric oxide synthase signaling.

    Drugs: ATP · Penbutolol · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  4. Pathway

    Norepinephrine Beta-1 Adrenergic Cardiac Action Pathway

    smpdb.ca/view/SMP0126438
    Drug action

    This calcium binds with troponin to activate tropomyosin which leads to contraction of the heart. Myosin, with an ADP and phosphate attached, binds to actin to form a cross bridge. … The voltage-gated calcium channels allow calcium to enter the cell. The calcium activates the ryanodine receptor on the sarcoplasmic reticulum in order to release more calcium into the cytosol.

    Drugs: ATP · Norepinephrine · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  5. Pathway

    Timolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126503
    Drug action

    Beta(1)-receptor blockade by timolol leads to a decrease in both heart rate and cardiac output during rest and exercise, and a decrease in both systolic and diastolic blood pressure. … When administered in the tablet form, it reduces blood pressure, heart rate, and cardiac output, and decreases sympathetic activity.

    Drugs: ATP · Timolol · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  6. Pathway

    Pindolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126651
    Drug action

    Increased intracellular calcium increase inotropy in the heart through calcium-induced exchange facilitated by the sarcoplasmic reticulum. … Beta-1 receptors are G-protein-coupled receptors (specifically Gs alpha subunit) whose action is exerted through the cyclic AMP (cAMP) and cAMP-dependent protein kinase action with resultant calcium ion

    Drugs: ATP · Pindolol · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  7. Pathway

    Dopamine Action Pathway

    smpdb.ca/view/SMP0125137
    Drug action

    Protein kinase activates calcium channels in the membrane, causing the channels to open and allow Ca2+ into the cell. … The high concentration of Ca2+ binds to troponin to cause cardiac muscle contractions and therefore, an increased heart rate.

    Drugs: Ascorbic acid · ATP · Norepinephrine · Dopamine · Calcium · Pyrroloquinoline Quinone
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent P/Q-type calcium channel subunit alpha-1A
  8. Pathway

    Dopamine Action Pathway

    smpdb.ca/view/SMP0127069
    Physiological

    Protein kinase activates calcium channels in the membrane, causing the channels to open and allow Ca2+ into the cell. … The high concentration of Ca2+ binds to troponin to cause cardiac muscle contractions and therefore, an increased heart rate.

    Drugs: Ascorbic acid · ATP · Norepinephrine · Dopamine · Calcium · Pyrroloquinoline Quinone
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent P/Q-type calcium channel subunit alpha-1A
  9. Pathway

    Bopindolol Action Pathway (New)

    smpdb.ca/view/SMP0126187
    Drug action

    cAMP, PKA, SRC and nitric oxide synthase signaling. … It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes.

    Drugs: ATP · Pindolol · Calcium · Mesoheme · Bopindolol
    Enzymes: Sodium/calcium exchanger 1, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
  10. Pathway

    Felodipine Metabolism Pathway

    smpdb.ca/view/SMP0000619
    Drug metabolism

    Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). … Felodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels.

    Drugs: Felodipine
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent L-type calcium channel subunit alpha-1C