Search
Castor Oil Action Pathway
smpdb.ca/view/SMP0174887Drug actionCastor Oil may also promote ulcer healing by increasing mucus and bicarbonate secretion and thickening the mucosal bilayer so the mucosa can generate new cells. … With reduced protein kinase A activation, this decreases the activity of the proton pump, fewer H+ ions are pumped into the lumen, reducing the acidity and thus allowing stomach ulcers to heal and reducing
Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid +1 moreLatanoprostene bunod Action Pathway
smpdb.ca/view/SMP0175202Drug actionLatanoprostene bunod may also promote ulcer healing by increasing mucus and bicarbonate secretion and thickening the mucosal bilayer so the mucosa can generate new cells. … With reduced protein kinase A activation, this decreases the activity of the proton pump, fewer H+ ions are pumped into the lumen, reducing the acidity and thus allowing stomach ulcers to heal and reducing
Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid +1 moreDinoprost tromethamine Action Pathway
smpdb.ca/view/SMP0175205Drug actionDinoprost tromethamine may also promote ulcer healing by increasing mucus and bicarbonate secretion and thickening the mucosal bilayer so the mucosa can generate new cells. … With reduced protein kinase A activation, this decreases the activity of the proton pump, fewer H+ ions are pumped into the lumen, reducing the acidity and thus allowing stomach ulcers to heal and reducing
Drugs: ATP · Dinoprost tromethamine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate +1 moreAtropine M2 Cardiac Muscle Contraction Action Pathway
smpdb.ca/view/SMP0124615Drug actionHigher cAMP concentration promote action potentials in the cells as well as increasing calcium influx from membrane channels. … All of these downstream effects increase heart rate and blood pressure therefore abolishing bradycardia and low blood pressure.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Tizanidine
smpdb.ca/view/SMP0125127Drug actionThis inhibits adenylyl cyclase and inactivates protein kinase A, thus decreasing calcium ion entry into the cell. … With reduced calcium entry in the presynaptic neuron, glutamate release is inhibited and less NMDA and AMPA receptors are activated, preventing depolarization of motor neurons and decreasing muscle contractions
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Dipyridamole Action Pathway
smpdb.ca/view/SMP0122804Drug actionThromboxane causes platelet activation and aggregation, therefore, inhibition of arachidonic release by cAMP leads to reduced thromboxane production and thus, less platelet activation and aggregation. … Dipyridamole is an oral coronary vasodilator and antiplatelet drug used in combination with other anti-coagulant drugs to prevent thrombosis in patients with valvular and vascular disorders.
Dipyridamole Phosphodiesterase Action Pathway
smpdb.ca/view/SMP0126489Drug actionDue to the anticoagulant and antiplatelet activity herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … Dipyridamole is metabolized in the liver to glucuronic acid and excreted out of the body via bile.
Amifampridine Action Pathway
smpdb.ca/view/SMP0126393Drug actionIncreased intracellular calcium enhances the exocytosis of acetylcholine-containing vesicles and enhances impulse transmission at the synapses. It is administered as an oral tablet. … This drug blocks presynaptic fast voltage-gated potassium channels, which prolongs the action potential and increases presynaptic calcium concentrations while increasing the acetylcholine concentrations
Drugs: Choline · ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 moreEnzymes: Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent calcium channel subunit alpha-2/delta-1Nucleotide Sugars Metabolism
smpdb.ca/view/SMP0000010MetabolicIn the case, the endoplasmic reticulum and golgi apparatus. … There are nine sugar nucleotides and they can be classified depending on the type of the nucleoside forming them: UDP-Glc, UDP-Gal, UDP-GlcNAc, UDP-GlcUA, UDP- Xyl, GDP-Man, GDP-Fuc and CMP-NeuNAc.
Galactosemia II (GALK)
smpdb.ca/view/SMP0000495DiseaseGalactokinase uses 1 ATP to catalyse the phosphorylation of α-D-galactose to galactose 1-phosphate and catalyses β-D-galactose to glucose 1-phosphate. … Galactokinase deficiency also called Galactosemia type II, is a rare inborn error of metabolism (IEM) and an autosomal recessive disorder of galactokinase caused by a mutation in the GALK1 gene on chromosome