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Tartrate-resistant acid phosphatase type 5
go.drugbank.com/bio_entities/BE0004487TargetHumansFunctions as a binuclear Fe(III)-Fe(II) acid phosphatase that hydrolyzes phosphate esters to alcohols and phosphate under acidic conditions (PubMed:1477968, PubMed:2775236). … Also involved in immune regulation and macrophage function, contributes to the breakdown of internalized pathogens within lysosomes (By similarity).
Polypeptides: Tartrate-resistant acid phosphatase type 5Synonyms: Purple acid phosphatase, Type 5 acid phosphataseProton-coupled amino acid transporter 2
go.drugbank.com/bio_entities/BE0004704TransporterHumansElectrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. … Extension of the backbone length, as in beta-alanine and 4-aminobutanoate or methylation of the amino group, as in sarcosine and N,N-dimethylglycine, are also tolerated but decrease transport efficiency
Polypeptides: Proton-coupled amino acid transporter 2Synonyms: Proton/amino acid transporter 2Y+L amino acid transporter 1
go.drugbank.com/bio_entities/BE0004769TransporterTargetHumansIn vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity) … Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions
Polypeptides: Y+L amino acid transporter 1Synonyms: Monocyte amino acid permease 2, y(+)L-type amino acid transporter 1Amino acid transporter heavy chain SLC3A2
go.drugbank.com/bio_entities/BE0012576TransporterHumansActs as a chaperone that facilitates biogenesis and trafficking of functional transporter heterodimers to the plasma membrane. … When associated with LAPTM4B, the SLC3A2/SLC7A5 heterodimer is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567).
Polypeptides: Amino acid transporter heavy chain SLC3A2Function: aromatic amino acid transmembrane transporter activityLeucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
go.drugbank.com/bio_entities/BE0018277TargetHumansIs also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). … Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)
Polypeptides: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1Synonyms: Leucine-rich repeat and immunoglobulin domain-containing protein 1Sodium-coupled neutral amino acid transporter 3
go.drugbank.com/bio_entities/BE0000285TargetTransporterHumansSymporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827). … Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity
Polypeptides: Sodium-coupled neutral amino acid transporter 3Synonyms: N-system amino acid transporter 1, System N amino acid transporter 1Gamma-aminobutyric acid receptor subunit alpha-2
go.drugbank.com/bio_entities/BE0000381TargetHumansThe alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic … GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-5
go.drugbank.com/bio_entities/BE0000471TargetHumansGABAARs containing alpha-5/GABRA5 subunits are mainly extrasynaptic and contribute to the tonic GABAergic inhibition in the hippocampus (By similarity). … GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-5Gamma-aminobutyric acid receptor subunit alpha-3
go.drugbank.com/bio_entities/BE0000523TargetHumansGABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:29053855).
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-3Long-chain-fatty-acid--CoA ligase 1
go.drugbank.com/bio_entities/BE0000639TargetEnzymeHumansCatalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233 … Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233).
Polypeptides: Long-chain-fatty-acid--CoA ligase 1Synonyms: Long-chain fatty acid-CoA ligase 2