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Serine/threonine-protein kinase TAO1
go.drugbank.com/bio_entities/BE0009392TargetHumansPhosphorylates MAP2K3, MAP2K6 and MARK2. … Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases.
Synonyms: Thousand and one amino acid protein kinase 1TIR domain-containing adapter molecule 1
go.drugbank.com/bio_entities/BE0016552TargetHumansDistinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively … Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303,
Synonyms: Proline-rich, vinculin and TIR domain-containing protein BE3 ubiquitin-protein ligase UHRF1
go.drugbank.com/bio_entities/BE0018559TargetHumansActs both as a histone reader and writer: specifically recognizes and binds (1) hemimethylated DNA at replication forks and (2) histone H3 trimethylated at 'Lys-9' and unmethylated at 'Arg-2' (H3K9me3 … Also mediates histone H3 'Lys-14' and 'Lys-23' ubiquitination (H3K14ub and H3K23ub) at lower level (PubMed:24013172, PubMed:27595565).
Synonyms: Ubiquitin-like PHD and RING finger domain-containing protein 1Fatty acid metabolism regulator protein
go.drugbank.com/bio_entities/BE0004232TargetEscherichia coli (strain K12)Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE (PubMed:9388199). … Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the
Synonyms: oleRSerine/threonine-protein kinase mTOR
go.drugbank.com/bio_entities/BE0002386TargetHumansIn response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed … Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213
Synonyms: Rapamycin and FKBP12 target 1Serine/threonine-protein kinase TAO3
go.drugbank.com/bio_entities/BE0009393TargetHumansPromotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). … Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade.
Synonyms: Thousand and one amino acid protein 3Alpha-ketoglutarate-dependent dioxygenase FTO
go.drugbank.com/bio_entities/BE0005795TargetHumansRNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720 … Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003).
Synonyms: Fat mass and obesity-associated proteinAurora kinase B
go.drugbank.com/bio_entities/BE0003404TargetHumansThe CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly ( … histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity).
Synonyms: Aurora- and IPL1-like midbody-associated protein 1Aurora kinase A
go.drugbank.com/bio_entities/BE0000991TargetHumansRequired for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). … Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome
Synonyms: Ipl1- and aurora-related kinase 1E3 ubiquitin-protein ligase HUWE1
go.drugbank.com/bio_entities/BE0016469TargetHumansRegulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). … Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956).
Synonyms: HECT, UBA and WWE domain-containing protein 1