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Displaying results 1771 - 1780 of 10000 in total
  1. Pathway

    Simvastatin Action Pathway (New)

    smpdb.ca/view/SMP0124578
    Drug action

    Statins are a class of medications that lower lipid levels and are administered to reduce illness and mortality in people who are at high risk of cardiovascular disease. … Simvastatin is a well-tolerated orally-administered synthetic statin that reduces total cholesterol levels, low-density lipoprotein (LDL)-cholesterol, triglyceride, and very-low-density lipoprotein (VLDL

    Drugs: Simvastatin · Calcium · Zinc · Cholesterol
  2. Indication

    Increased Intra Ocular Pressure (IOP)

    go.drugbank.com/conditions/DBCOND0049485
    Drugs: Betaxolol · Bimatoprost · Brimonidine · Brinzolamide · Carbamoylcholine · Carteolol +11 more
    Synonyms: Increase in intraocular pressure, Elevation in intraocular pressure
  3. Drug

    Ioversol

    go.drugbank.com/drugs/DB09134
    ApprovedInvestigational

    Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. … [L41780] Iodine has a high atomic density, which gives it the ability to attenuate X-rays.

    Categories: Compounds used in a research, industrial, or household setting, X-Ray Contrast ActivitySynonyms: N,N'-Bis (2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl) -glycolamido] -2,4,6-triiodoisophthalamide
  4. Indication

    Sore Throat

    go.drugbank.com/conditions/DBCOND0033906
    Drugs: Amylmetacresol · Amylocaine · Benzocaine · Benzoic acid · Cetrimonium · Cetylpyridinium +20 more
    Synonyms: Pain in throat, Pain in the pharynx
  5. Drug

    Acetazolamide

    go.drugbank.com/drugs/DB00819
    ApprovedInvestigationalVet approved

    It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual … Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition

    Categories: Cytochrome P-450 CYP3A Inhibitors, Heterocyclic Compounds, 1-RingSynonyms: N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide, N-[5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide
  6. Drug

    Risperidone

    go.drugbank.com/drugs/DB00734
    ApprovedInvestigational

    Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. … Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesInternational brands: Risperidal M-Tab
  7. Target

    Eph receptors

    go.drugbank.com/bio_entities/BE0028186
    TargetHumans

    Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis … In addition to its role in axonal guidance plays a role in synaptic plasticity.

    Polypeptides: Ephrin type-A receptor 1, Ephrin type-A receptor 10
  8. Target

    Linear primary-alkylsulfatase

    go.drugbank.com/bio_entities/BE0003744
    TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

    In addition, contributes to the in vivo virulence of P.aeruginosa by playing a central role in the degradation of mucin, a glycoprotein that is the primary component of the mucus overlaying the host epithelial … Plays a role in the degradation of both protein and carbohydrate moieties in mucin via the release of sulfate from mucin, D-galactose 6-sulfate (Gal-6S) and N-acetyl-D-glucosamine 6-sulfate (GlcNAc-6S)

    Polypeptides: Linear primary-alkylsulfataseSynonyms: Type III linear primary-alkylsulfatase
  9. Drug

    Levosalbutamol

    go.drugbank.com/drugs/DB13139
    Approved

    [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. … Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

    Categories: Adrenergic beta-2 Receptor Agonists, Cytochrome P-450 CYP3A InhibitorsSynonyms: R-salbutamol, (R)-salbutamol
  10. Drug

    Nizatidine

    go.drugbank.com/drugs/DB00585
    Approved

    A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.

    Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingSynonyms: N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamine