Search

Displaying results 171 - 180 of 5418 in total
  1. Target

    Cyclin-dependent kinase 2

    go.drugbank.com/bio_entities/BE0001072
    TargetHumans

    Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin … Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase (PubMed:10995386, PubMed:10995387

  2. Target

    Sialic acid-binding Ig-like lectin 7

    go.drugbank.com/bio_entities/BE0001648
    TargetHumans

    In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through

  3. Target

    Polyamine aminopropyltransferase

    go.drugbank.com/bio_entities/BE0001674
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.

  4. Target

    Palmitoyl-protein thioesterase 1

    go.drugbank.com/bio_entities/BE0004538
    TargetHumans

    Has thioesterase activity against fatty acid thioesters with 14 -18 carbons, including palmitoyl-CoA, S-palmitoyl-N-acetylcysteamine, and palmitoylated proteins (PubMed:12855696, PubMed:26731412, PubMed

  5. Target

    Prostaglandin E2 receptor EP4 subtype

    go.drugbank.com/bio_entities/BE0003522
    TargetHumans

    The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle.

  6. Target

    D-3-phosphoglycerate dehydrogenase

    go.drugbank.com/bio_entities/BE0000161
    TargetHumans

    Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate

  7. Target

    Gamma-aminobutyric acid receptor subunit alpha-3

    go.drugbank.com/bio_entities/BE0000523
    TargetHumans

    interface(s) (By similarity). … GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit

  8. Target

    Prostacyclin synthase

    go.drugbank.com/bio_entities/BE0000117
    TargetHumans

    Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323)

  9. Target

    Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

    go.drugbank.com/bio_entities/BE0001519
    TargetEscherichia coli (strain K12)

    Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA) (PubMed:1092681, PubMed:1092682).

  10. Target

    Fluorinase

    go.drugbank.com/bio_entities/BE0003167
    TargetStreptomyces cattleya

    Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine.