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Sodium channel protein type 8 subunit alpha
go.drugbank.com/bio_entities/BE0002084TargetHumansPore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass … Contributes to neuronal excitability by regulating action potential threshold and propagation (PubMed:24874546, PubMed:25239001, PubMed:25725044, PubMed:26900580, PubMed:29726066, PubMed:33245860, PubMed
Polypeptides: Sodium channel protein type 8 subunit alphaSynonyms: Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6Sodium/potassium-transporting ATPase subunit alpha-4
go.drugbank.com/bio_entities/BE0005031TransporterHumansPlays an essential for sperm motility, capacitation, and male fertility by maintaining ionic gradients required for flagellar function and signaling (By similarity) … Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze (PubMed:16861705).
Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-4Synonyms: Sodium pump subunit alpha-4Sodium channel protein type 7 subunit alpha
go.drugbank.com/bio_entities/BE0009590TargetHumansSodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. … While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMed:26537257, PubMed:35301303).
Polypeptides: Sodium channel protein type 7 subunit alphaSynonyms: Atypical sodium channel Nav2.1, Sodium channel protein type VII subunit alphaSodium channel protein type 1 subunit alpha
go.drugbank.com/bio_entities/BE0000141TargetHumansNavs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:14672992).
Polypeptides: Sodium channel protein type 1 subunit alphaSynonyms: Sodium channel protein brain I subunit alpha, Sodium channel protein type I subunit alphaSodium channel protein type 10 subunit alpha
go.drugbank.com/bio_entities/BE0000177TargetHumansAssuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their … Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes.
Polypeptides: Sodium channel protein type 10 subunit alphaSynonyms: Peripheral nerve sodium channel 3, Sodium channel protein type X subunit alphaSodium channel protein type 5 subunit alpha
go.drugbank.com/bio_entities/BE0000197TargetHumansNavs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed
Polypeptides: Sodium channel protein type 5 subunit alphaSynonyms: Sodium channel protein type V subunit alpha, Sodium channel protein cardiac muscle subunit alphaSodium channel protein type 9 subunit alpha
go.drugbank.com/bio_entities/BE0001143TargetHumansNavs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:17167479
Polypeptides: Sodium channel protein type 9 subunit alphaSynonyms: Peripheral sodium channel 1, Neuroendocrine sodium channelSodium channel protein type 2 subunit alpha
go.drugbank.com/bio_entities/BE0002081TargetHumansMediates the voltage-dependent sodium ion permeability of excitable membranes. … Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their
Polypeptides: Sodium channel protein type 2 subunit alphaSynonyms: Sodium channel protein brain II subunit alpha, Sodium channel protein type II subunit alphaSodium channel protein type 3 subunit alpha
go.drugbank.com/bio_entities/BE0002082TargetHumansNavs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … For instance, it controls the release of serotonin/5-hydroxytryptamine by enterochromaffin cells and is required for both glucagon- and glucose-induced insulin secretion in pancreatic endocrine cells (
Polypeptides: Sodium channel protein type 3 subunit alphaSynonyms: Voltage-gated sodium channel subtype III, Sodium channel protein brain III subunit alphaSodium/potassium-transporting ATPase subunit beta-1
go.drugbank.com/bio_entities/BE0004994TransporterTargetHumansMechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520) … Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs).
Polypeptides: Sodium/potassium-transporting ATPase subunit beta-1Synonyms: Sodium/potassium-dependent ATPase subunit beta-1