Sodium channel protein type 10 subunit alpha

BE0000177ProteinHumansSCN10A

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. It is acted on by 24 drugs in DrugBank.

Gene name
SCN10A
UniProtKB entry
Q9Y5Y9Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,956 residues · 220,624 Da
Also known as
hPN3 · Peripheral nerve sodium channel 3 · PN3 · Sodium channel protein type X subunit alpha · Voltage-gated sodium channel subunit alpha Nav1.8

Resolves to

Protein
UniProtQ9Y5Y9UniProt nameSCNAA_HUMAN
Gene
HGNCHGNC:10582NCBI Gene6336GenBank4838145GeneCardsSCN10A
Pharmacology
IUPHAR/GtoPdb585KEGGhsa:6336
Structure
PDB7WE4PDB7WELPDB7WFR
Drugs

What you can answer from here — as of September 07, 2019

24DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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48+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium channel protein type 10 subunit alpha, how selective are they, and which programs against it are still in active trials?

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