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Gamma-aminobutyric acid receptor subunit alpha-1
go.drugbank.com/bio_entities/BE0000795TargetHumansGABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … Together with rho subunits, may also control neuronal and glial GABAergic transmission in the cerebellum (By similarity)
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-1Long-chain-fatty-acid--CoA ligase 4
go.drugbank.com/bio_entities/BE0000996TargetHumansActs as an activator of ferroptosis by activating polyunsaturated fatty acids, especially arachidonate and adrenate, to their active form, generating the primary lipid-peroxidation substrates that contribute … Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233
Polypeptides: Long-chain-fatty-acid--CoA ligase 4Very long chain fatty acid elongase 4
go.drugbank.com/bio_entities/BE0002247EnzymeTargetHumansCatalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. … This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle.
Polypeptides: Very long chain fatty acid elongase 4Synonyms: ELOVL fatty acid elongase 4, Elongation of very long chain fatty acids protein 4Gamma-aminobutyric acid receptor subunit gamma-1
go.drugbank.com/bio_entities/BE0003593TargetHumansGABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790).
Polypeptides: Gamma-aminobutyric acid receptor subunit gamma-1Gamma-aminobutyric acid receptor subunit rho-3
go.drugbank.com/bio_entities/BE0003619TargetHumansRho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity).
Polypeptides: Gamma-aminobutyric acid receptor subunit rho-3G protein-coupled bile acid receptor 1
go.drugbank.com/bio_entities/BE0005788TargetHumansBile acid-binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase … Activated by bile acids, such as lithocholate, deoxycholate, chenodeoxycholate and cholate, in descending order (PubMed:12524422, PubMed:32698187).
Polypeptides: G protein-coupled bile acid receptor 1Synonyms: Membrane-type receptor for bile acidsLymphatic vessel endothelial hyaluronic acid receptor 1
go.drugbank.com/bio_entities/BE0010044TargetHumansBinds to pericellular hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (PubMed:26823460) … Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane.
Polypeptides: Lymphatic vessel endothelial hyaluronic acid receptor 1Synonyms: Hyaluronic acid receptorSialic acid-binding Ig-like lectin 8
go.drugbank.com/bio_entities/BE0020378TargetHumansRecognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. … Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619).
Polypeptides: Sialic acid-binding Ig-like lectin 8High affinity cationic amino acid transporter 1
go.drugbank.com/bio_entities/BE0000212TargetTransporterHumansHigh-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues
Polypeptides: High affinity cationic amino acid transporter 1Synonyms: System Y+ basic amino acid transporterGamma-aminobutyric acid receptor subunit alpha-6
go.drugbank.com/bio_entities/BE0000764TargetHumansGABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … Alpha-6/GABRA6 subunits are found at both synaptic and extrasynaptic sites (PubMed:8632757).
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-6