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Ephedrine A1-Adrenergic Vasoconstriction Action Pathway
smpdb.ca/view/SMP0126498Drug actionEphedrine is an alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion. It is administered as an intravenous injection, and can be found under the br...
Diltiazem Calcium Channel Vasodilation Action Pathway
smpdb.ca/view/SMP0126505Drug actionDiltiazem is a calcium channel blocker used to treat hypertension and to manage chronic stable angina. It can be found under the names Cardizem, Cartia, Matzim, Taztia, Tiadylt, and Tiazac. Diltiazem is a benzothiazepine derivative with ...
Nicotinic Acetylcholine
smpdb.ca/view/SMP0130480PhysiologicalNicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and periphe...
Dexchlorpheniramine maleate H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174954Drug actionDexchlorpheniramine maleate is a first generation H1-antihistamine used to treat allergic and vasomotor rhinitis, allergic conjunctivitis, and mild urticaria and angioedema. H1-antihistamines interfere with the agonist action of histamin...
GSK-1004723 H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174955Drug actionGSK-1004723 is an H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allerg...
Mitochondrial Complex II Deficiency
smpdb.ca/view/SMP0000548DiseaseMitochondrial complex II deficiency, which is also known as CII deficiency, is a rare form of an inherited inborn error of metabolism (IEM). CII deficiency is an autosomal recessive disorder that arises from mutations in the succinate de...
Enzymes: Citrate synthase, mitochondrialTrisalicylate-Choline Action Pathway
smpdb.ca/view/SMP0000703Drug actionTrisalicylate-Choline (also named Choline Magnesium Trisalicylate) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used to treat pain and fever.
Drugs: Glutamic acid · Glutathione · Dinoprostone · Calcium · Magnesium cation · Choline magnesium trisalicylate +5 moreEpoprostenol Action Pathway
smpdb.ca/view/SMP0126492Drug actionEpoprostenol is a platelet aggregator inhibitor also known under the brand name of Flolan and Veletri, used to manage hypertension in patients with heart failure. It is synthesized from prostaglandin endoperoxides in human vascular tissu...
Selexipag Action Pathway
smpdb.ca/view/SMP0126508Drug actionSelexipag is a non-prostanoid prostacyclin receptor agonist, also known as Uptravi typically used to treat pulmonary arterial hypertension. Selexipag is a selective prostacyclin receptor agonist, it is administered orally and is metaboli...
Relaxin IV Signaling Pathway
smpdb.ca/view/SMP0688465SignalingThe RXFP4 signaling pathway is initiated when the insulin-like peptide INSL5 binds to the RXFP4 receptor, a G protein-coupled receptor (GPCR) predominantly expressed in the human colon and hypothalamus. Upon ligand binding, RXFP4 primari...