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Displaying results 171 - 180 of 597 in total
  1. Pathway

    Pindolol Action Pathway

    smpdb.ca/view/SMP0000306
    Drug action

    Without renin, angiotensin II and aldosterone could not be produced, which ultimately prevent water retention and vasoconstriction. … Blocking beta-1 adrenergic receptor could prevent the binding of epinephrine and norepinephrine, which could efficiently reduce blood pressure and heart rate.

    Drugs: ATP · Pindolol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  2. Pathway

    Isradipine Action Pathway

    smpdb.ca/view/SMP0000378
    Drug action

    Calcium ion enters the cell and bind to calmodulin, and then calcium-bound calmodulin binds and activates myosin light chain kinase (MLCK). … There are at least 5 different types of calcium channels in human which are L-, N-, P/Q-, R- and T-type.

    Drugs: ATP · Isradipine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  3. Pathway

    Bopindolol Action Pathway

    smpdb.ca/view/SMP0000657
    Drug action

    Adrenaline (also known as epinephrine) can activate β1 adrenergic receptor so that the heart rate and output will be increased. … Bopindolol (also known as Sandonorm) is a selective β1 adrenergic receptor antagonist (beta blocker), which can be used for treatment of high blood pressure (hypertension) and irregular heartbeats

    Drugs: ATP · Potassium cation · Calcium · Bopindolol
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  4. Pathway

    Isoprenaline Action Pathway

    smpdb.ca/view/SMP0000663
    Drug action

    Isoprenaline can bind and inhibit beta-1 adrenergic receptor on both vascular smooth muscle, which lead to inhibition of vasoconstriction in peripheral blood vessels and adrenergic stimulation of endothelial … Isoprenaline (also known as isoproterenol) is a selective beta adrenergic bronchodilator that can be used for treating slow heart rate (bradycardia), heart block, and rarely for asthma.

    Drugs: ATP · Isoprenaline · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  5. Pathway

    Arbutamine Action Pathway

    smpdb.ca/view/SMP0000664
    Drug action

    Arbutamine has nonselective beta and weak alpha-1-adrenergic activity which causes increased chronotropic activity (increase in heart rate) and inotropic activity (increase myocardial contractility). … The system monitors heart rate and blood pressure throughout infusion with alarms for physiological changes or problems.

    Drugs: ATP · Arbutamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  6. Pathway

    Bevantolol Action Pathway

    smpdb.ca/view/SMP0000668
    Drug action

    This results in a decrease in preload and blood pressure. … Bevantolol hydrocholride, also known as bevantolol, is a cardioselective beta blocker prescribed to treat angina pectoris and hypertension.

    Drugs: ATP · Bevantolol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  7. Pathway

    Morphine Action Pathway

    smpdb.ca/view/SMP0000406
    Drug action

    G(i) also activates potassium channels and inactivates calcium channels causing the neuron to hyperpolarize. … The end result is decreased nerve conduction and reduced neurotransmitter release, which blocks the perception of pain signals.

    Drugs: ATP · Morphine · Norepinephrine · Dopamine · Potassium cation · Calcium +1 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Pathway

    Bupranolol Action Pathway

    smpdb.ca/view/SMP0000670
    Drug action

    Bupranolol is a nonselective beta-blocker with structural similarity to propanolol. Both drugs do not have intrinsic sympathomimetic activity. It competes with catecholamines for binding beta-1 adrenergic receptors in the heart to inhibi...

    Drugs: ATP · Potassium cation · Calcium · Bupranolol
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  9. Pathway

    Phenytoin (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000327
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … The extra sodium and calcium ions that entered the cell during the action potential are extruded via sodium-potassium ATPases and NCX and intra- and extracellular ion concentrations are restored.

    Drugs: Ademetionine · ATP · Phenytoin · Potassium cation · Calcium · Magnesium cation +3 more
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  10. Pathway

    Olfactory Transduction OR2W1

    smpdb.ca/view/SMP0713865
    Physiological

    Calcium influx further opens chloride (Cl⁻) channels, amplifying the depolarization. … This rise in cAMP opens cyclic nucleotide–gated ion channels, allowing sodium (Na⁺) and calcium (Ca²⁺) ions to flow into the cell, causing depolarization.

    Drugs: ATP · Calcium · Cyclohexanone · Cyclic adenosine monophosphate
    Enzymes: Calcium-activated chloride channel regulator 1