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Blast phase Chronic myeloid leukemia
go.drugbank.com/conditions/DBCOND0023499Synonyms: Chronic Myelogenous Leukemia in Blast Crisis, Chronic Myelogenous Leukemia (CML) in Blast CrisisAtracurium besylate
go.drugbank.com/drugs/DB00732ApprovedIts lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents … A non-depolarizing neuromuscular blocking agent with short duration of action.
Categories: Heterocyclic Compounds, 2-RingSynonyms: Besilato de atracurioHIV Wasting Syndrome
go.drugbank.com/conditions/DBCOND0000270Drugs: SomatotropinSynonyms: HIV disease resulting in wasting syndromePirfenidone
go.drugbank.com/drugs/DB04951ApprovedInvestigationalPirfenidone is a synthetic pyridone drug. … [A251370] It is an antifibrotic agent with anti-inflammatory and antioxidant properties [A251370] that is used to treat idiopathic pulmonary fibrosis (IPF),[L26801] which is a chronic, progressive form
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: PIRFENIDONE DR. REDDY?S, PULPIR® 267NADH dehydrogenase
go.drugbank.com/bio_entities/BE0003040TargetThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Can catalyze electron transfer from NADH to various electron acceptors which include, in addition to molecular oxygen, cytochrome c, 2,6 dichlorphenolindophenol, methylene blue, ferricyanide or P-nitroblue
Synonyms: H(2)O(2)-forming NADH oxidaseATP synthase peripheral stalk subunit OSCP, mitochondrial
go.drugbank.com/bio_entities/BE0009097TargetHumansIn vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). … During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable).
Synonyms: ATP synthase subunit ON-succinylamino acid racemase
go.drugbank.com/bio_entities/BE0002494TargetAmycolatopsis sp.Acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-phenylglycine and N-succinyl-methionine (PubMed:14705949, PubMed:24955846). Can catalyze the racemization of a broad range of N-acylamino acids,...
Synonyms: o-succinylbenzoate synthase, o-succinylbenzoic acid synthaseMeclizine
go.drugbank.com/drugs/DB00737ApprovedInvestigationalIt is used in the symptomatic treatment of motion sickness and control of vertigo associated with vestibular system diseases. … Meclizine is a histamine H1 antagonist with antiemetic and antivertigo properties.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: Motion Sickness II, Dramamine - NPsychophysiological Disorders
go.drugbank.com/conditions/DBCOND0172355Drugs: MelperoneSynonyms: Psychosomatic factor in physical condition, NOS, Psychosomatic factor in physical condition (finding)Buprenorphine
go.drugbank.com/drugs/DB00921ApprovedIllicitInvestigationalVet approved[A186215,A186218] It also means that opioid-dependent patients do not experience sedation or euphoria at the same rate that they might experience with more potent opioids, improving quality of life for … [L46571] Buprenorphine is commercially available as the brand name product Suboxone which is formulated in a 4:1 fixed-dose combination product along with [naloxone], a non-selective competitive opioid
Mixtures: SUBOXONE 8 MG/2 MG DILALTI TABLET, 7 ADET, Suboxone 8 mg/2 mg sublingual tabletsCategories: Drugs Used in Opioid Dependence, Drugs Used in Addictive Disorders