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Displaying results 181 - 190 of 134683 in total
  1. Pathway

    Amiodarone Action Pathway

    smpdb.ca/view/SMP0000665
    Drug action

    The drug inhibits Na,K-activated myocardial adenosine triphosphatase, calcium and potassium channels and beta adrenergic receptors causing an increase in ventricular and atrial muscle action duration. … Amiodarone is unique to other class III antiarrhythmic drugs due to its effect on beta adrenergic receptors, calcium channels and sodium channels.

    Drugs: ATP · Amiodarone · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  2. Pathway

    Gi Muscarinic Cardiac Muscle Contraction

    smpdb.ca/view/SMP0126951
    Physiological

    ), the activated receptor acts as a guanine nucleotide exchange factor to promote GDP release from and GTP binding to Gα, which drives dissociation of GTP-bound Gα from Gβγ. … GTP-bound Gα and Gβγ are then freed to activate their respective downstream signaling enzymes.

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium/calcium exchanger 1
  3. Pathway

    Aromatase Deficiency

    smpdb.ca/view/SMP0000565
    Disease

    Symptoms of decrease in estrogen and increase androgens such as testosterone can cause impaired female sexual development, unusual bone growth, insulin resistance, and a variety of other symptoms. … Aromatase converts androgens to estrogens which is vital for bone growth and regulation of blood sugar levels.

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
    Enzymes: Steryl-sulfatase
  4. Pathway

    17-beta Hydroxysteroid Dehydrogenase III Deficiency

    smpdb.ca/view/SMP0125781
    Disease

    disorder of the androgen and estrogen metabolism pathway. … This leads to an accumulation of androstenedione and dehydroepiandrosterone in the body, as well as a lack of testosterone produced. 17-KSR deficiency is characterized by an absence of testosterone in

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
    Enzymes: Steryl-sulfatase
  5. Pathway

    Finerenone Action Pathway

    smpdb.ca/view/SMP0126009
    Drug action

    In the principal cells of the collecting duct, sodium and water reabsorption occur, along with potassium excretion. … This effect on gene transcription leads to an upregulation of sodium channels in the apical membrane and Na+/K+ ATPase in the basolateral membrane, aiding an increase in Na+ and water reabsorption and

    Drugs: Potassium cation · Urea · Finerenone
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  6. Pathway

    Triamterene Action Pathway (New)

    smpdb.ca/view/SMP0126281
    Drug action

    sodium uptake and potassium secretion. … In the late distal tubule to the collecting duct, sodium ions are actively reabsorbed via ENaC on the luminal membrane and are extruded out of the cell into the peritubular medium by a sodium-potassium

    Drugs: Triamterene · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  7. Pathway

    Amiloride Action Pathway (New)

    smpdb.ca/view/SMP0126243
    Drug action

    This promotes the loss of sodium and water from the body, but without depleting potassium. … Amiloride is a pyrizine compound used to treat hypertension and congestive heart failure.It is a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells.

    Drugs: Amiloride · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Pathway

    Eplerenone Action Pathway

    smpdb.ca/view/SMP0122731
    Drug action

    In the principal cells of the collecting duct, sodium and water reabsorption occur, along with potassium excretion. … This effect on gene transcription leads to an upregulation of sodium channels in the apical membrane and Na+/K+ ATPase in the basolateral membrane, aiding an increase in Na+ and water reabsorption and

    Drugs: Eplerenone · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Spironolactone Action Pathway (New)

    smpdb.ca/view/SMP0126006
    Drug action

    In the principal cells of the distal convoluted tubule, sodium and water reabsorption occur, along with potassium excretion. … This effect on gene transcription leads to an upregulation of sodium channels in the apical membrane and Na+/K+ ATPase in the basolateral membrane, aiding an increase in Na+ and water reabsorption and

    Drugs: Spironolactone · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  10. Pathway

    Lactose Degradation

    smpdb.ca/view/SMP0000457
    Metabolic

    GLUT1 actively transports glucose and galactose with 2 sodium ions. … A sodium/potassium ATPase makes ATP by moving three sodium ions to the blood per two potassium ions that cross into the epithelial cell, giving the GLUT1 transporter energy to work.

    Drugs: ATP · Potassium cation · Lactose
    Enzymes: Sodium/glucose cotransporter 1, Sodium/potassium-transporting ATPase subunit alpha-1