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Displaying results 181 - 190 of 561 in total
  1. Target

    Gonadotropin-releasing hormone receptor

    go.drugbank.com/bio_entities/BE0000203
    TargetHumans

    This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling

  2. Target

    Gamma-aminobutyric acid type B receptor subunit 1

    go.drugbank.com/bio_entities/BE0000217
    TargetHumans

    Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). … Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating

  3. Target

    Alpha-2A adrenergic receptor

    go.drugbank.com/bio_entities/BE0000289
    TargetHumans

    adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium

  4. Target

    Sigma non-opioid intracellular receptor 1

    go.drugbank.com/bio_entities/BE0000290
    TargetHumans

    Regulates calcium efflux at the endoplasmic reticulum.

  5. Target

    Glutamate receptor ionotropic, NMDA 1

    go.drugbank.com/bio_entities/BE0000365
    TargetHumans

    NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). … Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:

  6. Target

    Glutamate receptor ionotropic, NMDA 2D

    go.drugbank.com/bio_entities/BE0000396
    TargetHumans

    NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). … Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:

  7. Target

    Cholecystokinin receptor type A

    go.drugbank.com/bio_entities/BE0000402
    TargetHumans

    This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

  8. Target

    Alpha-1A adrenergic receptor

    go.drugbank.com/bio_entities/BE0000501
    TargetHumans

    Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C (PubMed:37563160).

  9. Target

    Glucagon receptor

    go.drugbank.com/bio_entities/BE0000527
    TargetHumans

    Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system

  10. Target

    Kappa-type opioid receptor

    go.drugbank.com/bio_entities/BE0000632
    TargetHumans

    Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain.