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Displaying results 181 - 190 of 134474 in total
  1. Pathway

    Tivozanib Action Pathway

    smpdb.ca/view/SMP0126910
    Drug action

    Tivozanib works by inhibiting growth factor receptors, specifically targeting renal cell carcinoma. … In preclinical studies using mice and rats, tivozanib demonstrated its ability to inhibit tumor angiogenesis, slow tumor growth, and reduce vascular permeability.

    Drugs: Calcium · Tivozanib
    Enzymes: Coagulation factor X
  2. Pathway

    Heparin

    smpdb.ca/view/SMP0130950
    Physiological

    The activated AT then inactivates thrombin, factor Xa and other proteases. The rate of inactivation of these proteases by AT can increase by up to 1000-fold due to the binding of heparin. … The conformational change in AT on heparin-binding mediates its inhibition of factor Xa.

    Drugs: Heparin · Calcium
    Enzymes: Coagulation factor X
  3. Pathway

    Triflusal Action Pathway

    smpdb.ca/view/SMP0126548
    Drug action

    It also acts on many other cellular targets like NF kappa B, which is a gene expression regulatory factor for cycloxygenase-a and cytokines. … It is indicated as prophylaxis of thromboembolic disorders (prevention of strokes and myocardial infarction).

    Drugs: Adenosine phosphate · ATP · Adenosine · Calcium · Magnesium cation · Zinc +5 more
  4. Pathway

    Disulfiram Action Pathway

    smpdb.ca/view/SMP0000429
    Drug action

    Disulfiram can prevent alcohol metabolism by inhibiting acetaldehyde dehydrogenase in mitochondria, which lead to increased level of acetaldehyde, and eventually result in hangover (e.g. flushing, vomiting … Therefore, disulfiram is not suggested to take while patient consuming alcohol.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Adenosine phosphate · Tyrosine +27 more
    Enzymes: Macrophage migration inhibitory factor, Alcohol dehydrogenase 1B
  5. Pathway

    Celecoxib metabolism Pathway

    smpdb.ca/view/SMP0000644
    Metabolic

    Platelet activation and coagulation do not normally occur in intact blood vessels. After blood vessel injury, platelets adhere to the subendothelial collagen at the site of injury. … The accumulation of TxA2, ADP and thrombin mediates further platelet recruitment and signal amplification.

    Drugs: Celecoxib · Zinc · Mesoheme · Uridine-5'-Diphosphate
    Enzymes: Alcohol dehydrogenase 1B, Alcohol dehydrogenase 1A
  6. Pathway

    Tyrosinemia Type I

    smpdb.ca/view/SMP0000218
    Disease

    of tyrosine in the liver and kidneys. … Symptoms of tyrosinemia type I include jaundice and an enlarged liver, kidney dysfunction, as well as a failure to grow, as foods with high protein and amino acids lead to increased symptoms.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
    Enzymes: Alcohol dehydrogenase 1A, Macrophage migration inhibitory factor
  7. Pathway

    Monoamine Oxidase-A Deficiency (MAO-A)

    smpdb.ca/view/SMP0000533
    Disease

    and other effects. … Since serotonin helps to regulate emotions and mood, with epinephrine and norepinephrine regulating stress, the unnecessary presence of the chemicals in the brain can lead to poor impulse control, aggression

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
    Enzymes: Alcohol dehydrogenase 1A, Macrophage migration inhibitory factor
  8. Pathway

    Hawkinsinuria

    smpdb.ca/view/SMP0125590
    Disease

    pyroglutamic acid in urine; and L-tyrosine in plasma. … Symptoms include ketosis, metabolic acidosis, swimming-pool odor, and mental retardation. Treatment includes a low-protein diet and vitamin C.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
    Enzymes: Alcohol dehydrogenase 1A, Macrophage migration inhibitory factor
  9. Pathway

    Tyrosine Metabolism

    smpdb.ca/view/SMP0000006
    Metabolic

    human brain that express PMNT. … Thyroid hormones are produced and released by the thyroid gland and include triiodothyronine (T3) and thyroxine (T4). These two hormones are responsible for regulating metabolism.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
    Enzymes: Alcohol dehydrogenase 1A, Macrophage migration inhibitory factor
  10. Pathway

    Tyrosinemia, Transient, of the Newborn

    smpdb.ca/view/SMP0000494
    Disease

    A transient defect in tyrosine metabolism is a common aminoacidopathy in the premature and full-term human infant. … and derivatives.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
    Enzymes: Alcohol dehydrogenase 1A, Macrophage migration inhibitory factor