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Metal cation symporter ZIP14
go.drugbank.com/bio_entities/BE0009903TransporterHumansand immunity (PubMed:15642354, PubMed:27231142, PubMed:29621230). … Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity).
Synonyms: Zrt- and Irt-like protein 14Mitogen-activated protein kinase kinase kinase 20
go.drugbank.com/bio_entities/BE0005595TargetHumansActivates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). … Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways
Synonyms: Leucine zipper- and sterile alpha motif-containing kinase, Sterile alpha motif- and leucine zipper-containing kinase AZKMaltose-6'-phosphate glucosidase
go.drugbank.com/bio_entities/BE0001309TargetBacillus subtilis (strain 168)Is also able to significantly catalyze the hydrolysis of both 6-phospho-alpha- and 6-phospho-beta-glucosides containing activated leaving groups such as p-nitrophenol and does so with retention and inversion … Hydrolyzes maltose-6'-phosphate and trehalose-6'-phosphate.
Synonyms: 6-phosphoryl-O-alpha-D-glucopyranosyl:phosphoglucohydrolaseSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
go.drugbank.com/bio_entities/BE0010396TargetHumansAs neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or … Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity).
Synonyms: Mitotic growth and transcription activatorGlutamate decarboxylase
go.drugbank.com/bio_entities/BE0010293TargetHumansCatalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.
Synonyms: Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), isoform CRA_bSerine/threonine-protein kinase DCLK2
go.drugbank.com/bio_entities/BE0009430TargetHumansProtein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. … May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity
Synonyms: Doublecortin-like and CAM kinase-like 2Mitochondrial peptide methionine sulfoxide reductase
go.drugbank.com/bio_entities/BE0000170TargetEnzymeHumansPlays a crucial role in repairing oxidized methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens … Has an important function as a repair enzyme for proteins that have been inactivated by oxidation (PubMed:10452521, PubMed:12039877).
Synonyms: Peptide Met(O) reductaseHepatitis A virus cellular receptor 2
go.drugbank.com/bio_entities/BE0010551TargetHumansInhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). … Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function.
Synonyms: T-cell immunoglobulin and mucin domain-containing protein 3Peptide methionine sulfoxide reductase MsrA
go.drugbank.com/bio_entities/BE0001618TargetShigella flexneriHas an important function as a repair enzyme for proteins that have been inactivated by oxidation.
Synonyms: Peptide Met(O) reductaseTumor necrosis factor ligand superfamily member 13B
go.drugbank.com/bio_entities/BE0000999TargetHumansTogether, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. … Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors.
Synonyms: TNF- and APOL-related leukocyte expressed ligand 1