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Sertraline Mechanism of Action Action Pathway New
smpdb.ca/view/SMP0126512Drug actionSertraline is a selective serotonin reuptake inhibitor (SSRI) indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual ...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Chlorprothixene Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126577Drug actionChlorprothixene is a thioxanthene antipsychotic. Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the ...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Zuclopenthixol Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126579Drug actionZuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. Zuclopenthixol is a typi...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Cariprazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126662Drug actionCariprazine is indicated for the treatment of schizophrenia in adults to manage both positive and negative symptoms. It is also indicated to monotherapy for acute management of manic or mixed episodes associated with bipolar I disorder (...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Flibanserin Serotonin Action Action Pathway
smpdb.ca/view/SMP0126786Drug actionFlibansetrin has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin binds equally to 5-HT1A and 5-HT2A receptors. However, under higher levels of brain 5-...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Embramine H1-Antihistamine Action
smpdb.ca/view/SMP0062622Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Drugs: CalciumThenyldiamine H1-Antihistamine Action
smpdb.ca/view/SMP0062624Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Drugs: CalciumClocinizine H1-Antihistamine Action
smpdb.ca/view/SMP0062788Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Drugs: CalciumZiconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway
smpdb.ca/view/SMP0126347Drug actionVoltage-gated calcium channels (VGCCs) are important regulatory components of neural signalling, including type-N voltage-gated calcium channels. … Ziconotide inhibits Voltage-dependent N-type calcium channels in presynaptic neurons.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Hydroxyzine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175076Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1