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Sialic acid-binding Ig-like lectin 7
go.drugbank.com/bio_entities/BE0001648TargetHumansPutative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. … Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide).
Polypeptides: Sialic acid-binding Ig-like lectin 7Gamma-aminobutyric acid receptor subunit beta-1
go.drugbank.com/bio_entities/BE0002344TargetHumansGABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain one or two GABA active binding sites located at the alpha and beta … Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness
Polypeptides: Gamma-aminobutyric acid receptor subunit beta-1Gamma-aminobutyric acid receptor subunit beta-2
go.drugbank.com/bio_entities/BE0002346TargetHumansGABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness
Polypeptides: Gamma-aminobutyric acid receptor subunit beta-2Gamma-aminobutyric acid receptor subunit gamma-2
go.drugbank.com/bio_entities/BE0003592TargetHumansGABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites (By similarity).
Polypeptides: Gamma-aminobutyric acid receptor subunit gamma-2Gamma-aminobutyric acid receptor subunit rho-2
go.drugbank.com/bio_entities/BE0003598TargetHumansRho-2 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). … Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity).
Polypeptides: Gamma-aminobutyric acid receptor subunit rho-2Long-chain-fatty-acid--CoA ligase ACSBG1
go.drugbank.com/bio_entities/BE0004272TargetHumansCatalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed … Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:10954726)
Polypeptides: Long-chain-fatty-acid--CoA ligase ACSBG1Function: long-chain fatty acid-CoA ligase activityLong-chain fatty acid transport protein 2
go.drugbank.com/bio_entities/BE0009868EnzymeHumansCan also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260). May contribute to the synthesis of sphingosine-1-phosphate (PubMed:24269233). … Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells
Polypeptides: Long-chain fatty acid transport protein 2Synonyms: Fatty acid transport protein 2, Long-chain-fatty-acid--CoA ligaseSialic acid-binding Ig-like lectin 10
go.drugbank.com/bio_entities/BE0018431TargetHumansIn association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). … In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction
Polypeptides: Sialic acid-binding Ig-like lectin 10Very long chain fatty acid elongase 6
go.drugbank.com/bio_entities/BE0019860EnzymeHumansCatalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. … Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle.
Polypeptides: Very long chain fatty acid elongase 6Synonyms: Fatty acid elongase 2, ELOVL fatty acid elongase 6Gamma-aminobutyric acid receptor subunit rho-1
go.drugbank.com/bio_entities/BE0000129TargetHumansRho-1 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). … Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:37659407
Polypeptides: Gamma-aminobutyric acid receptor subunit rho-1