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Displaying results 11 - 20 of 446 in total
  1. Target

    Calcium and integrin-binding protein 1

    go.drugbank.com/bio_entities/BE0008691
    TargetHumans

    Forms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (PubMed:30068544, PubMed:32917726) … Also promotes cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.

    Polypeptides: Calcium and integrin-binding protein 1Synonyms: Calcium- and integrin-binding protein
  2. Target

    Multidrug and toxin extrusion protein 2

    go.drugbank.com/bio_entities/BE0004752
    TransporterHumans

    Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. … Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney

    Polypeptides: Multidrug and toxin extrusion protein 2
  3. Target

    Nucleolar and coiled-body phosphoprotein 1

    go.drugbank.com/bio_entities/BE0005819
    TargetHumans

    It has intrinsic GTPase and ATPase activities (PubMed:9016786) … processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).

    Polypeptides: Nucleolar and coiled-body phosphoprotein 1
  4. Target

    Cysteine and glycine-rich protein 1

    go.drugbank.com/bio_entities/BE0009098
    TargetHumans

    Could play a role in neuronal development

    Polypeptides: Cysteine and glycine-rich protein 1
  5. Target

    Sodium- and chloride-dependent taurine transporter

    go.drugbank.com/bio_entities/BE0009148
    TransporterHumans

    Can also mediate transport of beta-alanine, hypotaurine and gamma-aminobutyric acid (GABA) (PubMed:39837997, PubMed:40108165, PubMed:40789850, PubMed:41269860, PubMed:8010975) … Mediates sodium- and chloride-dependent transport of taurine, a key amino acid (PubMed:31345061, PubMed:31903486, PubMed:39837997, PubMed:40108165, PubMed:40108449, PubMed:40615403, PubMed:40789850, PubMed

    Polypeptides: Sodium- and chloride-dependent taurine transporter
  6. Target

    TRAF2 and NCK-interacting protein kinase

    go.drugbank.com/bio_entities/BE0009399
    TargetHumans

    MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed … Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development.

    Polypeptides: TRAF2 and NCK-interacting protein kinase
  7. Target

    Sodium- and chloride-dependent GABA transporter 1

    go.drugbank.com/bio_entities/BE0000249
    TargetHumans

    Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:30132828). … +), Cl(-) and GABA (By similarity).

    Polypeptides: Sodium- and chloride-dependent GABA transporter 1Function: gamma-aminobutyric acid transmembrane transporter activity
  8. Target

    Sodium- and chloride-dependent creatine transporter 1

    go.drugbank.com/bio_entities/BE0000375
    TargetTransporterHumans

    Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity)

    Polypeptides: Sodium- and chloride-dependent creatine transporter 1
  9. Target

    Signal transducer and activator of transcription 5B

    go.drugbank.com/bio_entities/BE0000891
    TargetHumans

    Signal transducer and transcription activator that mediates cellular responses to cytokines, hormones and growth factors (PubMed:29844444, PubMed:9188471). … Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.

    Polypeptides: Signal transducer and activator of transcription 5B
  10. Target

    Disintegrin and metalloproteinase domain-containing protein 10

    go.drugbank.com/bio_entities/BE0002404
    TargetHumans

    Involved in the development and maturation of glomerular and coronary vasculature (By similarity). … Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177). Enhances the cleavage of CHL1 by BACE1 (By similarity).

    Polypeptides: Disintegrin and metalloproteinase domain-containing protein 10