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Displaying results 11 - 20 of 470 in total
  1. Target

    Multidrug and toxin extrusion protein 2

    go.drugbank.com/bio_entities/BE0004752
    TransporterHumans

    Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively … Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate.

    Polypeptides: Multidrug and toxin extrusion protein 2
  2. Target

    Nucleolar and coiled-body phosphoprotein 1

    go.drugbank.com/bio_entities/BE0005819
    TargetHumans

    It has intrinsic GTPase and ATPase activities (PubMed:9016786) … processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).

    Polypeptides: Nucleolar and coiled-body phosphoprotein 1
  3. Target

    Cysteine and glycine-rich protein 1

    go.drugbank.com/bio_entities/BE0009098
    TargetHumans

    Could play a role in neuronal development

    Polypeptides: Cysteine and glycine-rich protein 1
  4. Target

    Sodium- and chloride-dependent taurine transporter

    go.drugbank.com/bio_entities/BE0009148
    TransporterHumans

    Can also mediate transport of beta-alanine, hypotaurine and gamma-aminobutyric acid (GABA) (PubMed:39837997, PubMed:40108165, PubMed:40789850, PubMed:41269860, PubMed:8010975) … Mediates sodium- and chloride-dependent transport of taurine, a key amino acid (PubMed:31345061, PubMed:31903486, PubMed:39837997, PubMed:40108165, PubMed:40108449, PubMed:40615403, PubMed:40789850, PubMed

    Polypeptides: Sodium- and chloride-dependent taurine transporter
  5. Target

    TRAF2 and NCK-interacting protein kinase

    go.drugbank.com/bio_entities/BE0009399
    TargetHumans

    Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. … MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed

    Polypeptides: TRAF2 and NCK-interacting protein kinase
  6. Target

    Sodium- and chloride-dependent GABA transporter 1

    go.drugbank.com/bio_entities/BE0000249
    TargetHumans

    Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:30132828). … +), Cl(-) and GABA (By similarity).

    Polypeptides: Sodium- and chloride-dependent GABA transporter 1Function: gamma-aminobutyric acid transmembrane transporter activity
  7. Target

    Sodium- and chloride-dependent creatine transporter 1

    go.drugbank.com/bio_entities/BE0000375
    TargetTransporterHumans

    Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity)

    Polypeptides: Sodium- and chloride-dependent creatine transporter 1
  8. Target

    Signal transducer and activator of transcription 5B

    go.drugbank.com/bio_entities/BE0000891
    TargetHumans

    Signal transducer and transcription activator that mediates cellular responses to cytokines, hormones and growth factors (PubMed:29844444, PubMed:9188471). … Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.

    Polypeptides: Signal transducer and activator of transcription 5B
  9. Target

    Disintegrin and metalloproteinase domain-containing protein 10

    go.drugbank.com/bio_entities/BE0002404
    TargetHumans

    During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). … Involved in the development and maturation of glomerular and coronary vasculature (By similarity).

    Polypeptides: Disintegrin and metalloproteinase domain-containing protein 10
  10. Target

    Disintegrin and metalloproteinase domain-containing protein 28

    go.drugbank.com/bio_entities/BE0003872
    TargetHumans

    May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L.

    Polypeptides: Disintegrin and metalloproteinase domain-containing protein 28Synonyms: Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L, Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II