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Displaying results 11 - 20 of 2572 in total
  1. Pathway

    Glycine N-Methyltransferase Deficiency

    smpdb.ca/view/SMP0000222
    Disease

    This disorder is characterized by a large accumulation of methionine in the plasma and transaminases in the serum. Symptoms of the disorder include hepatomegaly. … Glycine N-methyltransferase deficiency, also called GNMT deficiency, is an autosomal recessive disorder of methionine metabolism caused by a defective glycine N-methyltransferase (GNMT).

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: Methionine synthase, Methionine--tRNA ligase, cytoplasmic
  2. Pathway

    Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type

    smpdb.ca/view/SMP0000570
    Disease

    Methionine synthase deficiency is characterized by an increase in homocysteine levels in the body and excreted in the urine, as well as decreased levels of methionine in the blood. … It is caused by a mutation in the MTR gene which encodes the enzyme methionine synthase.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: Methionine synthase, Methionine--tRNA ligase, cytoplasmic
  3. Pathway

    Glycine N-Methyltransferase Deficiency

    smpdb.ca/view/SMP0125681
    Disease

    This disorder is characterized by a large accumulation of methionine in the plasma and transaminases in the serum. Symptoms of the disorder include hepatomegaly. … Glycine N-methyltransferase deficiency, also called GNMT deficiency, is an autosomal recessive disorder of methionine metabolism caused by a defective glycine N-methyltransferase (GNMT).

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: Methionine synthase, Methionine--tRNA ligase, cytoplasmic
  4. Pathway

    Hypermethioninemia

    smpdb.ca/view/SMP0125679
    Disease

    This outputted compound through the its respective pathway may be turned back into cysteine methionine.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: Methionine synthase, Methionine-R-sulfoxide reductase B3
  5. Pathway

    Cystathionine beta-Synthase Deficiency

    smpdb.ca/view/SMP0125678
    Disease

    Treatment includes folic acid, vitamin B6, vitamin B12, and a methionine-restricted diet. … A deficiency in this enzyme results in accumulation of L-cystathionine, homocysteine, and L-homocystine in plasma and urine; and L-methionine and ornithine in plasma.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: Methionine synthase, Methionine-R-sulfoxide reductase B3
  6. Pathway

    Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)

    smpdb.ca/view/SMP0125682
    Disease

    A defect in this enzyme results in accumulation of homocysteine and methionine in both plasma and urine. … Methylenetetrahydrofolate reductase catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: Methionine synthase, Methionine-R-sulfoxide reductase B3
  7. Pathway

    Betaine Metabolism

    smpdb.ca/view/SMP0000123
    Metabolic

    In the liver, betaine functions as a methyl donor similar to choline, folic acid, S-adenosyl methionine and vitamin B12.

    Drugs: Tetrahydrofolic acid · Ademetionine · Choline · Methionine · NADH · ATP +8 more
    Enzymes: Methionine synthase, Methionine adenosyltransferase 2 subunit beta
  8. Pathway

    Metabolism and Physiological Effects of N-Acetylmethionine

    smpdb.ca/view/SMP0126707
    Metabolic

    In particular, N-Acetylmethionine can be biosynthesized from L-methionine and acetyl-CoA by the enzyme methionine N-acetyltransferase. … N-Acetyl-L-methionine or N-Acetylmethionine, belongs to the class of organic compounds known as N-acyl-alpha amino acids.

    Drugs: Methionine · N-Acetylmethionine
  9. Pathway

    Spermidine and Spermine Biosynthesis

    smpdb.ca/view/SMP0000445
    Metabolic

    Spermidine originates from the action of spermidine synthase, which converts the methionine derivative S-adenosylmethionine and the ornithine derivative putrescine into spermidine 5'-methylthioadenosine

    Drugs: Pyridoxal phosphate · Ademetionine · Spermine · Ornithine · Methionine · ATP +6 more
    Enzymes: Methionine adenosyltransferase 2 subunit beta
  10. Pathway

    Selenoamino Acid Metabolism

    smpdb.ca/view/SMP0000029
    Metabolic

    Phospholipids are membrane components in P. aeruginosa. The major phospholipids of P. aeruginosa are phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. All phospholipids contain sn-glycerol-3-phosphate esterified with fatty...

    Drugs: Pyridoxal phosphate · Adenosine phosphate · Serine · Alanine · ATP · Adenosine +3 more
    Enzymes: Methionine--tRNA ligase, cytoplasmic, Methionine adenosyltransferase 2 subunit beta