Search

Displaying results 11 - 20 of 225 in total
  1. Target

    Protein O-GlcNAcase

    go.drugbank.com/bio_entities/BE0005827
    TargetHumans

    Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:11148210, PubMed:11788610, PubMed:20673219, PubMed:22365600, PubMed:24088714, PubMed:28939839, PubMed:37962578). … Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578).

    Polypeptides: Protein O-GlcNAcaseSynonyms: Nuclear cytoplasmic O-GlcNAcase and acetyltransferase
  2. Target

    Sialate O-acetylesterase

    go.drugbank.com/bio_entities/BE0019865
    EnzymeHumans

    Catalyzes the removal of O-acetyl ester groups from position 9 of the free diacetylated sialate N-acetyl-9-O-acetylneuraminate (Neu5,9Ac2) in the cytosol and of the diacetylated sialate residues of sialylglycoconjugates … Together with the sialate-O-acetyltransferase they regulate the balance of acetylated sialoglycoconjugates, key players in various processes such as cell-cell interactions, host-pathogen recognition, and

    Polypeptides: Sialate O-acetylesteraseSynonyms: Sialic acid-specific 9-O-acetylesterase
  3. Target

    Diacylglycerol O-acyltransferase 2

    go.drugbank.com/bio_entities/BE0008719
    EnzymeTargetHumans

    Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. … Required for synthesis and storage of intracellular triglycerides (PubMed:27184406). Probably plays a central role in cytosolic lipid accumulation.

    Polypeptides: Diacylglycerol O-acyltransferase 2Synonyms: Retinol O-fatty-acyltransferase, Acyl-CoA retinol O-fatty-acyltransferase
  4. Target

    Diacylglycerol O-acyltransferase 1

    go.drugbank.com/bio_entities/BE0012021
    TargetHumans

    Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:16214399, PubMed:18768481, PubMed:28420705, PubMed:32433610, … Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:16214399

    Polypeptides: Diacylglycerol O-acyltransferase 1Synonyms: Retinol O-fatty-acyltransferase, Acyl-CoA retinol O-fatty-acyltransferase
  5. Target

    Sterol O-acyltransferase 1

    go.drugbank.com/bio_entities/BE0000105
    TargetEnzymeHumans

    Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). … or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614)

    Polypeptides: Sterol O-acyltransferase 1
  6. Target

    Peroxisomal carnitine O-octanoyltransferase

    go.drugbank.com/bio_entities/BE0000373
    TargetHumans

    Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester

    Polypeptides: Peroxisomal carnitine O-octanoyltransferaseFunction: carnitine O-octanoyltransferase activity
  7. Target

    Chloramphenicol 3-O phosphotransferase

    go.drugbank.com/bio_entities/BE0001493
    TargetEnzymeStreptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

    Inactivates chloramphenicol by catalyzing the transfer of the gamma-phosphate of ATP to the antibiotic's C-3' hydroxyl group.

    Polypeptides: Chloramphenicol 3-O phosphotransferase
  8. Target

    Sterol O-acyltransferase 2

    go.drugbank.com/bio_entities/BE0004608
    TargetEnzymeHumans

    Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:11294643). … May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa (PubMed:11294643)

    Polypeptides: Sterol O-acyltransferase 2
  9. Target

    O-acetyl-ADP-ribose deacetylase

    go.drugbank.com/bio_entities/BE0003188
    TargetEscherichia coli (strain K12)

    Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate (PubMed:21257746, PubMed:26481419). Down-regulates ribonuclease 3 (RNase III) activity. … Overexpression inhibits biofilm formation via an RNase III-independent pathway. This inhibition is RpoS-dependent (PubMed:24267348, PubMed:28582517).

    Polypeptides: O-acetyl-ADP-ribose deacetylase
  10. Target

    Carminomycin 4-O-methyltransferase DnrK

    go.drugbank.com/bio_entities/BE0001712
    TargetStreptomyces peucetius

    In vivo, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the 4-O-position of carminomycin to form daunorubicin. … Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy

    Polypeptides: Carminomycin 4-O-methyltransferase DnrKSynonyms: Anthracycline 4-O-methyltransferase