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Mitogen-activated protein kinase kinase kinase kinase 3
go.drugbank.com/bio_entities/BE0009472TargetHumansActivator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. … MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed
Polypeptides: Mitogen-activated protein kinase kinase kinase kinase 3Mitogen-activated protein kinase kinase kinase kinase 4
go.drugbank.com/bio_entities/BE0009473TargetHumansActivator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. … MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed
Polypeptides: Mitogen-activated protein kinase kinase kinase kinase 4Mitogen-activated protein kinase kinase kinase kinase 5
go.drugbank.com/bio_entities/BE0009474TargetHumansMay play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway
Polypeptides: Mitogen-activated protein kinase kinase kinase kinase 5Dual specificity mitogen-activated protein kinase kinase 4
go.drugbank.com/bio_entities/BE0010122TargetHumansWith MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. … Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14
Polypeptides: Dual specificity mitogen-activated protein kinase kinase 4Synonyms: Stress-activated protein kinase kinase 1Lymphokine-activated killer T-cell-originated protein kinase
go.drugbank.com/bio_entities/BE0018659TargetHumansWhen phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage
Polypeptides: Lymphokine-activated killer T-cell-originated protein kinasePeroxisome proliferator-activated receptor gamma coactivator 1-alpha
go.drugbank.com/bio_entities/BE0020703TargetHumansRequired for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity) … Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed
Polypeptides: Peroxisome proliferator-activated receptor gamma coactivator 1-alphaG protein-activated inward rectifier potassium channel 2
go.drugbank.com/bio_entities/BE0001030TargetHumansThis potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G protein-coupled receptors
Polypeptides: G protein-activated inward rectifier potassium channel 2Function: G-protein activated inward rectifier potassium channel activityG protein-activated inward rectifier potassium channel 4
go.drugbank.com/bio_entities/BE0002218TargetHumansInward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as externa...
Polypeptides: G protein-activated inward rectifier potassium channel 4Function: G-protein activated inward rectifier potassium channel activitySmall conductance calcium-activated potassium channel protein 1
go.drugbank.com/bio_entities/BE0004425TargetHumansThe current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:8781233 … Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values,
Polypeptides: Small conductance calcium-activated potassium channel protein 1Function: calcium-activated potassium channel activitySmall conductance calcium-activated potassium channel protein 2
go.drugbank.com/bio_entities/BE0004426TargetHumansThe inward rectification could be due to a blockade of the outward current by intracellular divalent cations such as calcium and magnesium and could also be due to an intrinsic property of the channel … Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin
Polypeptides: Small conductance calcium-activated potassium channel protein 2