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Displaying results 191 - 200 of 561 in total
  1. Target

    Glutamate receptor 1

    go.drugbank.com/bio_entities/BE0000640
    TargetHumans

    Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable. … conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium

  2. Target

    Peptidyl-prolyl cis-trans isomerase FKBP1A

    go.drugbank.com/bio_entities/BE0000695
    TargetHumans

    May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

  3. Target

    Alpha-1D adrenergic receptor

    go.drugbank.com/bio_entities/BE0000715
    TargetHumans

    Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C (PubMed:7746284).

  4. Target

    Chloride channel protein 2

    go.drugbank.com/bio_entities/BE0000765
    TargetHumans

    The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated calcium channels and increased expression of aldosterone

  5. Target

    Vitamin D3 receptor

    go.drugbank.com/bio_entities/BE0000779
    TargetHumans

    Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (PubMed:12016314, PubMed:32354638)

  6. Target

    Glutamate receptor 2

    go.drugbank.com/bio_entities/BE0000829
    TargetHumans

    conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium

  7. Target

    Glutamate receptor 3

    go.drugbank.com/bio_entities/BE0000831
    TargetHumans

    excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of calcium

  8. Target

    Neuronal acetylcholine receptor subunit beta-2

    go.drugbank.com/bio_entities/BE0000850
    TargetHumans

    Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter … Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation

  9. Target

    Calpastatin

    go.drugbank.com/bio_entities/BE0000904
    TargetHumans

    Specific inhibition of calpain (calcium-dependent cysteine protease).

  10. Target

    Pro-epidermal growth factor

    go.drugbank.com/bio_entities/BE0000953
    TargetHumans

    EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via e...

    Function: calcium ion binding