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Tumor necrosis factor ligand superfamily member 13B
go.drugbank.com/bio_entities/BE0000999TargetHumansTogether, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. … Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors.
Synonyms: TNF- and APOL-related leukocyte expressed ligand 1E3 ubiquitin ligase TRAF3IP2
go.drugbank.com/bio_entities/BE0011632TargetHumansand MAPkinase pathways (PubMed:19825828) … Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B
Synonyms: Connection to IKK and SAPK/JNKE3 ubiquitin-protein ligase CHIP
go.drugbank.com/bio_entities/BE0021260TargetHumansUbiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (PubMed:19567782). … Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256).
Synonyms: STIP1 homology and U box-containing protein 1Excretory Secretory (ES) proteins
go.drugbank.com/bio_entities/BE0009630TargetFasciola hepaticaThiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host. … Thiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host.
Synonyms: Newly excysted juvenile proteins 5 and 7Serine/threonine-protein kinase TAO2
go.drugbank.com/bio_entities/BE0004632TargetHumansIsoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. … Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases.
Synonyms: Thousand and one amino acid protein kinase 2Metallo-beta-lactamase type 2
go.drugbank.com/bio_entities/BE0001212TargetEnzymeBacteroides fragilisConfers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
Synonyms: Carbapenem and cephamycin resistanceProtein O-GlcNAcase
go.drugbank.com/bio_entities/BE0005827TargetHumansDeglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578). … Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714)
Synonyms: Nuclear cytoplasmic O-GlcNAcase and acetyltransferase4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
go.drugbank.com/bio_entities/BE0004121TargetMycobacterium tuberculosisCatalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and … Is also able to catalyze the hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) and the synthetic analog 8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid (HOPODA).
Polypeptides: 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolaseSynonyms: MCP hydrolase, HOPDA hydrolaseAngiopoietin-1 receptor
go.drugbank.com/bio_entities/BE0003379TargetHumansTyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, … kinase and the AKT1 signaling cascades.
Synonyms: Tyrosine kinase with Ig and EGF homology domains-2Metal cation symporter ZIP8
go.drugbank.com/bio_entities/BE0009901TransporterHumansTransports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion (PubMed:27166256, PubMed:31699897). … Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:27166256).
Synonyms: Zrt- and Irt-like protein 8