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Displaying results 191 - 200 of 134502 in total
  1. Pathway

    Levobupivacaine Action Pathway

    smpdb.ca/view/SMP0000397
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Levobupivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons.

    Drugs: ATP · Norepinephrine · Dopamine · Levobupivacaine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  2. Pathway

    Lidocaine (Local Anaesthetic) Action Pathway

    smpdb.ca/view/SMP0000398
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Lidocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Lidocaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: NADH · ATP · Lidocaine · Norepinephrine · Dopamine · Potassium cation +3 more
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  3. Pathway

    Oxybuprocaine Action Pathway

    smpdb.ca/view/SMP0000400
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Oxybuprocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons.

    Drugs: ATP · Norepinephrine · Oxybuprocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  4. Pathway

    Procaine Action Pathway

    smpdb.ca/view/SMP0000402
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Procaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Procaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Procaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  5. Pathway

    Hydromorphone Action Pathway

    smpdb.ca/view/SMP0000410
    Drug action

    The binding of hydromorphone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.

    Drugs: ATP · Hydromorphone · Norepinephrine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  6. Pathway

    Hydrocodone Action Pathway

    smpdb.ca/view/SMP0000411
    Drug action

    The binding of hydrocodone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.

    Drugs: ATP · Norepinephrine · Hydrocodone · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  7. Pathway

    Alfentanil Action Pathway

    smpdb.ca/view/SMP0000413
    Drug action

    The binding of alfentanil will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.

    Drugs: ATP · Norepinephrine · Alfentanil · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  8. Pathway

    Sufentanil Action Pathway

    smpdb.ca/view/SMP0000417
    Drug action

    and decrease in cAMP production. … It also inhibits nociceptive neurotransmitter release and induces membrane hyperpolarization. Analgesia, anesthesia, and respiratory depression are a consequence of remifentanial’s action.

    Drugs: ATP · Norepinephrine · Sufentanil · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  9. Pathway

    Desipramine Action Pathway

    smpdb.ca/view/SMP0000423
    Drug action

    It does so by competing for the same binding site as norepinephrine on the sodium-dependent noradraneline transporter (SLC6A2) and by competing with serotonin for binding to the sodium-dependent serotonin … This increases the concentrations of both norepinephrine and serotonin in their respective synapses and reverses the state of low concentrations of both neurotransmitters found in depression.

    Drugs: ATP · Norepinephrine · Dopamine · Desipramine · Potassium cation · Calcium +1 more
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  10. Pathway

    Escitalopram Action Pathway

    smpdb.ca/view/SMP0000425
    Drug action

    It does so by competing for the same binding site as serotonin on the the sodium-dependent serotonin transporter (SLC6A4). … CREB-1 enters the nucleus and affects transcription of brain-derived neurotrophic factor (BDNF).

    Drugs: ATP · Norepinephrine · Dopamine · Escitalopram · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter