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Ziprasidone H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175141Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Chlorpromazine - Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126487Drug actionProchlorperazine and chlorpromazine are examples of this class of Phenothiazines. Phenothiazines antagonize the D2 receptor, most notably in the area postrema in the brain. IV, PO, and rectal (PR) formulations are available. Side effects...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Amoxapine SSRI Action Pathway
smpdb.ca/view/SMP0126502Drug actionAmoxapine is a second-generation tricyclic dibenzoxazepine antidepressant, chemically distinct from the dibenzodiazepines, dibenzocycloheptenes, and dibenzoxepines. It has a mild sedative component to its action. The mechanism of its cli...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Citalopram Mechanism of Action Action Pathway New
smpdb.ca/view/SMP0126506Drug actionCitalopram is a selective serotonin reuptake inhibitor used to manage symptoms of depression, anxiety, mood and eating disorders. Off-label indications include but are not limited to: treatment of sexual dysfunction, post-stroke behavior...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Paroxetine Mechanism of Action Action Pathway New
smpdb.ca/view/SMP0126510Drug actionParoxetine is a selective serotonin reuptake inhibitor. It is used to manage major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric dis...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Sertraline Mechanism of Action Action Pathway New
smpdb.ca/view/SMP0126512Drug actionSertraline is a selective serotonin reuptake inhibitor (SSRI) indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual ...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Chlorprothixene Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126577Drug actionChlorprothixene is a thioxanthene antipsychotic. Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the ...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Zuclopenthixol Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126579Drug actionZuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. Zuclopenthixol is a typi...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Cariprazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126662Drug actionCariprazine is indicated for the treatment of schizophrenia in adults to manage both positive and negative symptoms. It is also indicated to monotherapy for acute management of manic or mixed episodes associated with bipolar I disorder (...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Flibanserin Serotonin Action Action Pathway
smpdb.ca/view/SMP0126786Drug actionFlibansetrin has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin binds equally to 5-HT1A and 5-HT2A receptors. However, under higher levels of brain 5-...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1