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4-hydroxy-3-methylbut-2-enyl diphosphate reductase
go.drugbank.com/bio_entities/BE0004045TargetEscherichia coli (strain K12)Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). … In vitro, can also hydrate acetylenes to aldehydes and ketones via anti-Markovnikov/Markovnikov addition (PubMed:22948824).
Synonyms: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductaseAtrial natriuretic peptide receptor 1
go.drugbank.com/bio_entities/BE0000556TargetHumansand subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499) … Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499).
Synonyms: ANP-AAtrial natriuretic peptide receptor 2
go.drugbank.com/bio_entities/BE0000997TargetHumansReceptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth
Synonyms: ANP-BAtrial natriuretic peptide receptor 3
go.drugbank.com/bio_entities/BE0002426TargetHumansMay function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. … Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production
Synonyms: ANP-C1-deoxy-D-xylulose 5-phosphate reductoisomerase
go.drugbank.com/bio_entities/BE0001575TargetEscherichia coli (strain K12)Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Synonyms: 2-C-methyl-D-erythritol 4-phosphate synthaseGlutamate receptor ionotropic, NMDA 2D
go.drugbank.com/bio_entities/BE0000396TargetHumansComponent of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed: … NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity).
Synonyms: N-methyl D-aspartate receptor subtype 2DPeptidoglycan editing factor PgeF
go.drugbank.com/bio_entities/BE0002757TargetEscherichia coli (strain K12)Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (PubMed:31978345). Also has adenosine deaminase activity (PubMed:31978345). … Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine (PubMed:31978345).
Synonyms: S-methyl-5'-thioadenosine phosphorylase, S-methyl-5'-thioadenosine phosphorylase YfiHGlutamate receptor ionotropic, NMDA 1
go.drugbank.com/bio_entities/BE0000365TargetHumansComponent of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed: … NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity).
Synonyms: N-methyl-D-aspartate receptor subunit NR1Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
go.drugbank.com/bio_entities/BE0000573TargetHumansShort and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF … Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug (PubMed:8660691)
Synonyms: 2-methyl branched chain acyl-CoA dehydrogenaseADP/ATP translocase 2
go.drugbank.com/bio_entities/BE0000709TargetHumansproduction and cause mitochondrial thermogenesis (By similarity). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).
Synonyms: ANT 2