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Protein S100-A13
go.drugbank.com/bio_entities/BE0000885TargetHumansThe calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity) … Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion.
Polypeptides: Protein S100-A13Synonyms: S100 calcium-binding protein A13Bromodomain-containing protein 4
go.drugbank.com/bio_entities/BE0010747TargetHumansAccording to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidence … Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed
Polypeptides: Bromodomain-containing protein 4Synonyms: Protein HUNK1Tyrosine-protein kinase Lck
go.drugbank.com/bio_entities/BE0000842TargetHumansPhosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501) … Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells (PubMed:2470098).
Polypeptides: Tyrosine-protein kinase LckSynonyms: Protein YT16, T cell-specific protein-tyrosine kinaseProtein S100-B
go.drugbank.com/bio_entities/BE0001177TargetHumansSmall zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:20950652, PubMed:6487634). … May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (PubMed:22399290)
Polypeptides: Protein S100-BSynonyms: S-100 protein beta chain, S-100 protein subunit betaIndian hedgehog protein
go.drugbank.com/bio_entities/BE0010596TargetHumansThe C-terminal part of the precursor displays an autoproteolysis and a cholesterol transferase activity, resulting (1) in the cleavage of the full-length protein into two parts, indian hedgehog protein … N-product and C-product and (2) covalent attachment of a cholesterol moiety to the C-terminus of the newly generated N-product (By similarity).
Polypeptides: Indian hedgehog proteinChemotaxis protein CheY
go.drugbank.com/bio_entities/BE0002023TargetEscherichia coli (strain K12)Overexpression of CheY in association with MotA and MotB improves motility of a ycgR disruption, suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein
Polypeptides: Chemotaxis protein CheYProtein S100-A6
go.drugbank.com/bio_entities/BE0002950TargetHumansMay function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in
Polypeptides: Protein S100-A6Synonyms: S100 calcium-binding protein A6, Growth factor-inducible protein 2A9Protein argonaute-2
go.drugbank.com/bio_entities/BE0020979TargetHumansRequired for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide R...
Polypeptides: Protein argonaute-2Synonyms: Protein slicer, PAZ Piwi domain proteinProtein disulfide-isomerase
go.drugbank.com/bio_entities/BE0002467TargetHumansAt the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. … Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins.
Polypeptides: Protein disulfide-isomeraseSynonyms: Cellular thyroid hormone-binding proteinTyrosine-protein kinase transforming protein Src
go.drugbank.com/bio_entities/BE0001401TargetRSV-SR-EThis phosphoprotein, required for both the initiation and the maintenance of neoplastic transformation, is a protein kinase that catalyzes the phosphorylation of tyrosine residues in vitro.
Polypeptides: Tyrosine-protein kinase transforming protein Src