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Peroxisome proliferator-activated receptor gamma
go.drugbank.com/bio_entities/BE0000215TargetHumansLigand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism … Ligand-binding results in a conformational change in the receptor, promoting dissociation of repressors and recruitment of coactivators, and subsequent activation of target gene expression (PubMed:16150867
Polypeptides: Peroxisome proliferator-activated receptor gammaSynonyms: Nuclear receptor subfamily 1 group C member 3Interferon alpha/beta receptor 2
go.drugbank.com/bio_entities/BE0000385TargetHumansTogether with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:10556041, PubMed:21854986, PubMed:26424569
Polypeptides: Interferon alpha/beta receptor 2Synonyms: IFN-alpha/beta receptor 2, Type I interferon receptor 2Glutamate receptor ionotropic, NMDA 2C
go.drugbank.com/bio_entities/BE0000454TargetHumansComponent of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:36309015). Particip...
Polypeptides: Glutamate receptor ionotropic, NMDA 2CSynonyms: N-methyl D-aspartate receptor subtype 2C, Glutamate [NMDA] receptor subunit epsilon-3Atrial natriuretic peptide receptor 1
go.drugbank.com/bio_entities/BE0000556TargetHumansReceptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315).
Polypeptides: Atrial natriuretic peptide receptor 1Synonyms: Atrial natriuretic peptide receptor type AFree fatty acid receptor 1
go.drugbank.com/bio_entities/BE0000688TargetHumansMay also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). … G protein-coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis.
Polypeptides: Free fatty acid receptor 1Synonyms: G protein-coupled receptor 40Fibroblast growth factor receptor 2
go.drugbank.com/bio_entities/BE0000748TargetHumansTyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, … Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling
Polypeptides: Fibroblast growth factor receptor 2Synonyms: Keratinocyte growth factor receptorGlutamate receptor ionotropic, NMDA 2A
go.drugbank.com/bio_entities/BE0000760TargetHumansComponent of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:20890276, PubMed:23933818, PubMed:23...
Polypeptides: Glutamate receptor ionotropic, NMDA 2ASynonyms: N-methyl D-aspartate receptor subtype 2A, Glutamate [NMDA] receptor subunit epsilon-1Glutamate receptor ionotropic, kainate 2
go.drugbank.com/bio_entities/BE0000826TargetHumansL-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system (By similarity). … Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid (PubMed:7536611, PubMed:8730589, PubMed:14511640
Polypeptides: Glutamate receptor ionotropic, kainate 2Synonyms: Glutamate receptor 6, Excitatory amino acid receptor 4Glutamate receptor ionotropic, kainate 4
go.drugbank.com/bio_entities/BE0000827TargetHumansIonotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel. Cannot form functional channels on its own (PubMed:8263508).
Polypeptides: Glutamate receptor ionotropic, kainate 4Synonyms: Glutamate receptor KA-1, Excitatory amino acid receptor 1Glutamate receptor ionotropic, kainate 5
go.drugbank.com/bio_entities/BE0000828TargetHumansIonotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid.
Polypeptides: Glutamate receptor ionotropic, kainate 5Synonyms: Glutamate receptor KA-2, Excitatory amino acid receptor 2