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Displaying results 2441 - 2450 of 8696 in total
  1. Target

    Interleukin-1 receptor-associated kinase 1

    go.drugbank.com/bio_entities/BE0009452
    TargetHumans

    Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation.

    Polypeptides: Interleukin-1 receptor-associated kinase 1
  2. Target

    Receptor tyrosine-protein kinase erbB-3

    go.drugbank.com/bio_entities/BE0009917
    TargetHumans

    Tyrosine kinase receptor that, despite substitutions of key catalytic residues in the kinase domain, retains residual catalytic activity enabling autophosphorylation (PubMed:9148746, PubMed:20351256). … May also be activated by additional ligands including CSPG5 and EGFL6; the latter triggers assembly of an ERBB2/ERBB3/ITGB3 signaling complex leading to ERK phosphorylation and cell proliferation (PubMed

    Polypeptides: Receptor tyrosine-protein kinase erbB-3Synonyms: Tyrosine kinase-type cell surface receptor HER3
  3. Target

    Advanced glycation end product-specific receptor

    go.drugbank.com/bio_entities/BE0010032
    TransporterTargetHumans

    Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). … Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein

    Polypeptides: Advanced glycation end product-specific receptorSynonyms: Receptor for advanced glycation end products, Advanced glycosylation end product-specific receptor
  4. Target

    Hepatitis A virus cellular receptor 2

    go.drugbank.com/bio_entities/BE0010551
    TargetHumans

    Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. … Receptor for LGALS9 (PubMed:16286920, PubMed:24337741).

    Polypeptides: Hepatitis A virus cellular receptor 2Synonyms: T-cell immunoglobulin mucin receptor 3
  5. Target

    Baculoviral IAP repeat-containing protein 7

    go.drugbank.com/bio_entities/BE0010707
    TargetHumans

    May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions (PubMed:16729033).

    Polypeptides: Baculoviral IAP repeat-containing protein 7
  6. Target

    C-C chemokine receptor type 3

    go.drugbank.com/bio_entities/BE0013339
    TargetHumans

    May also act as a possible functional receptor for NARS1 (PubMed:30171954) … G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines (PubMed:28994588).

    Polypeptides: C-C chemokine receptor type 3Synonyms: Eosinophil eotaxin receptor
  7. Target

    C-C chemokine receptor type 8

    go.drugbank.com/bio_entities/BE0013343
    TargetHumans

    G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed:23999500, PubMed:35041514). Regulates monocyte and eosinophil chemotaxis.

    Polypeptides: C-C chemokine receptor type 8Synonyms: Chemokine receptor-like 1, CC chemokine receptor CHEMR1
  8. Target

    Oncostatin-M-specific receptor subunit beta

    go.drugbank.com/bio_entities/BE0018846
    TargetHumans

    Functions as a shared membrane-bound signal-transducing subunit in two distinct receptor complexes, the type II OSM receptor (heterodimer composed of OSMR and IL6ST) and the IL31 receptor complex (heterodimer … Functionally, OSM signaling via OSMR/IL6ST regulates many processes including cell proliferation, cell differentiation, cytokine production, whereas the IL31 signaling via OSMR/IL31RA is particularly important

    Polypeptides: Oncostatin-M-specific receptor subunit betaSynonyms: IL-31 receptor subunit beta, Interleukin-31 receptor subunit beta
  9. Target

    Taste receptor type 2 member 4

    go.drugbank.com/bio_entities/BE0020472
    TargetHumans

    Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.

    Polypeptides: Taste receptor type 2 member 4Function: bitter taste receptor activity
  10. Target

    Short transient receptor potential channel 6

    go.drugbank.com/bio_entities/BE0020965
    TargetHumans

    Mediates calcium entry following G(q)-coupled receptor or receptor tyrosine kinase activation, which triggers phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositides and production of diacylglycerol

    Polypeptides: Short transient receptor potential channel 6Synonyms: Transient receptor protein 6