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Daprodustat
go.drugbank.com/drugs/DB11682ApprovedInvestigationalAs a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces erythropoiesis. … anemia of CKD but not for non-dialysis patients with anemia of CKD.
Categories: Blood and Blood Forming Organs, Amino Acids, Peptides, and ProteinsCyanocobalamin reductase / alkylcobalamin dealkylase
go.drugbank.com/bio_entities/BE0002175TargetHumansto shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). … Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin
Synonyms: Methylmalonic aciduria and homocystinuria type C proteinVesicular inhibitory amino acid transporter
go.drugbank.com/bio_entities/BE0002308TransporterHumansAntiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. … The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity).
Synonyms: GABA and glycine transporterAll-trans-retinol 13,14-reductase
go.drugbank.com/bio_entities/BE0002320TargetHumansDoes not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A.
Synonyms: PPAR-alpha-regulated and starvation-induced gene proteinComplement C4-A
go.drugbank.com/bio_entities/BE0004685TargetHumansPrecursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2Complement C4-B
go.drugbank.com/bio_entities/BE0004686TargetHumansPrecursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3Lomitapide
go.drugbank.com/drugs/DB08827Approved[A7367] Lomitapide was first approved by the FDA in December 2012 and the EMA in July 2013 as an adjunct to a low-fat diet and other lipid-lowering treatments.[A275444, A275446] … by extremely high levels of low-density lipoprotein cholesterol (LDL-C) and premature atherosclerotic cardiovascular disease.
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
go.drugbank.com/bio_entities/BE0000525TargetHumansMay play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091) … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371).
Synonyms: Gene associated with retinoic and IFN-induced mortality 19 protein, Gene associated with retinoic and interferon-induced mortality 19 proteinTechnetium Tc-99m sestamibi
go.drugbank.com/drugs/DB09161ApprovedInvestigationalFollowing intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by the myocardium, parathyroid, and/or breast tissue. … infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.
Categories: Indicators and ReagentsCannabidiol
go.drugbank.com/drugs/DB09061ApprovedInvestigationalOn June 25th, 2018, Epidiolex was approved by the FDA to be the first CBD-based product available on the US market. … If not provided in their activated form (such as through synthetic forms of THC like [DB00470] or [DB00486]), THC and CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A
Categories: Cannabinoids and similars