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Gamma-aminobutyric acid receptor subunit alpha-4
go.drugbank.com/bio_entities/BE0000478TargetHumansGABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-4Synonyms: GABA(A) receptor subunit alpha-4Tyrosine-protein phosphatase non-receptor type 1
go.drugbank.com/bio_entities/BE0000623TargetHumansMay also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET … May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.
Polypeptides: Tyrosine-protein phosphatase non-receptor type 1C-X-C chemokine receptor type 4
go.drugbank.com/bio_entities/BE0000919TargetHumansAlso acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). … Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10074102, PubMed:10452968, PubMed:10644702
Polypeptides: C-X-C chemokine receptor type 4Synonyms: SDF-1 receptor, Stromal cell-derived factor 1 receptorLow-density lipoprotein receptor-related protein 2
go.drugbank.com/bio_entities/BE0000942TargetTransporterHumansMediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). … Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity).
Polypeptides: Low-density lipoprotein receptor-related protein 2Tumor necrosis factor receptor superfamily member 5
go.drugbank.com/bio_entities/BE0001196TargetHumansReceptor for TNFSF5/CD40LG (PubMed:31331973).
Polypeptides: Tumor necrosis factor receptor superfamily member 5Synonyms: CD40L receptorProlow-density lipoprotein receptor-related protein 1
go.drugbank.com/bio_entities/BE0002110TargetHumansMay modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). … Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:1702392, PubMed:26142438).
Polypeptides: Prolow-density lipoprotein receptor-related protein 1Synonyms: Apolipoprotein E receptor, Alpha-2-macroglobulin receptorGamma-aminobutyric acid receptor subunit beta-3
go.drugbank.com/bio_entities/BE0002345TargetHumansGABAARs containing alpha-1, beta-3 and epsilon subunits may also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (By similarity … Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness
Polypeptides: Gamma-aminobutyric acid receptor subunit beta-3Synonyms: GABA(A) receptor subunit beta-3Tumor necrosis factor receptor superfamily member 10B
go.drugbank.com/bio_entities/BE0003433TargetHumansReceptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor.
Polypeptides: Tumor necrosis factor receptor superfamily member 10BSynonyms: Death receptor 5, TRAIL receptor 2Tumor necrosis factor receptor superfamily member 9
go.drugbank.com/bio_entities/BE0003463TargetHumansReceptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable)
Polypeptides: Tumor necrosis factor receptor superfamily member 9Synonyms: 4-1BB ligand receptorGamma-aminobutyric acid receptor subunit gamma-3
go.drugbank.com/bio_entities/BE0003594TargetHumansGamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GA...
Polypeptides: Gamma-aminobutyric acid receptor subunit gamma-3Synonyms: GABA(A) receptor subunit gamma-3