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Diacylglycerol acyltransferase/mycolyltransferase Ag85C
go.drugbank.com/bio_entities/BE0001688TargetMycobacterium tuberculosisThe antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They...
Synonyms: Antigen 85 complex CNADH dehydrogenase [ubiquinone] 1 subunit C2
go.drugbank.com/bio_entities/BE0000173TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Synonyms: Complex I-B14.5bSuccinate dehydrogenase
go.drugbank.com/bio_entities/BE0010253EnzymeTargetHumansIron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed … Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to
Synonyms: Succinate dehydrogenase complex subunit D, Flavoprotein subunit of complex IIProstaglandin E synthase 3
go.drugbank.com/bio_entities/BE0002480TargetHumansCytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-depende...
Synonyms: Progesterone receptor complex p23Proteasome subunit alpha type-2
go.drugbank.com/bio_entities/BE0003911TargetHumansComponent of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Synonyms: Multicatalytic endopeptidase complex subunit C3Proteasome subunit beta type-7
go.drugbank.com/bio_entities/BE0003920TargetHumansWithin the 20S core complex, PSMB7 displays a trypsin-like activity … Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.
Synonyms: Multicatalytic endopeptidase complex chain ZProteasome subunit alpha type-3
go.drugbank.com/bio_entities/BE0003912TargetHumansComponent of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Synonyms: Multicatalytic endopeptidase complex subunit C8Serine/threonine-protein kinase mTOR
go.drugbank.com/bio_entities/BE0002386TargetHumansThe mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). … The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197).
Synonyms: FKBP12-rapamycin complex-associated protein, FK506-binding protein 12-rapamycin complex-associated protein 1Proteasome subunit beta type-2
go.drugbank.com/bio_entities/BE0002349TargetHumansNon-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Synonyms: Multicatalytic endopeptidase complex subunit C7-IPhospholipid-transporting ATPase IA
go.drugbank.com/bio_entities/BE0001001TargetHumansCatalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures … The flippase complex ATP8A1:CDC50A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity
Synonyms: P4-ATPase flippase complex alpha subunit ATP8A1