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Proteasome subunit alpha type-3
go.drugbank.com/bio_entities/BE0003912TargetHumansComponent of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Synonyms: Multicatalytic endopeptidase complex subunit C8Serine/threonine-protein kinase mTOR
go.drugbank.com/bio_entities/BE0002386TargetHumansThe mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). … The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197).
Synonyms: FKBP12-rapamycin complex-associated protein, FK506-binding protein 12-rapamycin complex-associated protein 1Proteasome subunit beta type-2
go.drugbank.com/bio_entities/BE0002349TargetHumansNon-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Synonyms: Multicatalytic endopeptidase complex subunit C7-IPhospholipid-transporting ATPase IA
go.drugbank.com/bio_entities/BE0001001TargetHumansCatalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures … The flippase complex ATP8A1:CDC50A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity
Synonyms: P4-ATPase flippase complex alpha subunit ATP8A1Phospholipid-transporting ATPase VA
go.drugbank.com/bio_entities/BE0011629TransporterHumansCatalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane
Synonyms: P4-ATPase flippase complex alpha subunit ATP10AProteasome subunit beta type-1
go.drugbank.com/bio_entities/BE0002347TargetHumansNon-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Synonyms: Multicatalytic endopeptidase complex subunit C5Cyclin-dependent kinase 8
go.drugbank.com/bio_entities/BE0002224TargetHumansPhosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression (PubMed:10993082). … Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.
Synonyms: Mediator complex subunit CDK8Proteasome subunit alpha type-4
go.drugbank.com/bio_entities/BE0003913TargetHumansComponent of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Synonyms: Multicatalytic endopeptidase complex subunit C9Atypical kinase COQ8A, mitochondrial
go.drugbank.com/bio_entities/BE0009381TargetHumansAtypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:21296186, PubMed:25498144, PubMed:25540914, PubMed:27499294, PubM...
Synonyms: Chaperone activity of bc1 complex-likeProteasome subunit beta type-6
go.drugbank.com/bio_entities/BE0003919TargetHumansComponent of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Synonyms: Multicatalytic endopeptidase complex delta chain