Search

Displaying results 2721 - 2730 of 10000 in total
  1. Indication

    Pulmonary Embolism Acute Massive

    go.drugbank.com/conditions/DBCOND0138765
    Drugs: Alteplase · Streptokinase · Urokinase
    Synonyms: PE, PE - Pulmonary embolism
  2. Pathway

    Disopyramide Cardiac Action Pathway

    smpdb.ca/view/SMP0126247
    Drug action

    Disopyramide is a class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. It can be found under the brand names Norpace and Rythmodan. A class I anti-arrhythmic agent (one that interferes directly with the d...

    Drugs: Disopyramide · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  3. Pathway

    Mexiletine Action Pathway (New)

    smpdb.ca/view/SMP0126263
    Drug action

    Mexiletine is a class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment. Mexiletine (INN) (sold under the brand names Mexitil and Namuscla) is a medication used to treat abnormal h...

    Drugs: Mexiletine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  4. Pathway

    Procainamide Action Pathway (New)

    smpdb.ca/view/SMP0126265
    Drug action

    Procainamide is a class 1A antidysrythmIc as well as an anesthetic that is used to treat ventricular dysrhythmias, tachycardia and atrial fibrillation. Procainamide mainly inhibits sodium channels protein type 5 subunit alpha but also in...

    Drugs: Procainamide · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  5. Pathway

    Moricizine Action Pathway

    smpdb.ca/view/SMP0126950
    Drug action

    Moricizine is an antiarrhythmic used to treat arrhythmias (irregular heartbeats) and to maintain normal heart rate. it acts on heart muscles by inhibiting inward sodium channels. This results in a slowed atrioventricular nodal and His-Pu...

    Drugs: Moricizine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  6. Drug

    Gepirone

    go.drugbank.com/drugs/DB12184
    Approved

    Gepirone, an azapirone, is a pharmacologic analog of [buspirone] that acts selectively on the pre- and post-synaptic 5HT<sub>1A</sub> receptors. … It was not until an extended-release formulation of gepirone was made available that gepirone became a potential candidate for a new antidepressant.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring
  7. Drug

    Lefamulin

    go.drugbank.com/drugs/DB12825
    Approved

    A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. … Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia.

    Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  8. Drug

    Testosterone

    go.drugbank.com/drugs/DB00624
    ApprovedInvestigational

    Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.

    Categories: 3-Oxoandrosten (4) Derivatives, P-glycoprotein inhibitorsSynonyms: 4-androsten-17β-ol-3-one, 17beta-hydroxy-4-androsten-3-one
  9. Target

    Sensor histidine kinase EnvZ

    go.drugbank.com/bio_entities/BE0002079
    TargetEscherichia coli (strain K12)

    Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (PubMed:2997120, PubMed:3536870). EnvZ functions as a membrane-associated protein kinase that...

    Synonyms: perA
  10. Target

    Dipeptidyl-peptidase IV

    go.drugbank.com/bio_entities/BE0003194
    TargetMyxococcus xanthus

    Synonyms: Prolyl endopeptidase Pep