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Gamma-aminobutyric acid receptor subunit beta-1
go.drugbank.com/bio_entities/BE0002344TargetHumansBeta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness
Polypeptides: Gamma-aminobutyric acid receptor subunit beta-1Synonyms: GABA(A) receptor subunit beta-1Gamma-aminobutyric acid receptor subunit beta-2
go.drugbank.com/bio_entities/BE0002346TargetHumansBeta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness
Polypeptides: Gamma-aminobutyric acid receptor subunit beta-2Synonyms: GABA(A) receptor subunit beta-2Tumor necrosis factor receptor superfamily member 11A
go.drugbank.com/bio_entities/BE0003461TargetHumansReceptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed:9878548).
Polypeptides: Tumor necrosis factor receptor superfamily member 11ASynonyms: Receptor activator of NF-KB, Osteoclast differentiation factor receptorC-X-C chemokine receptor type 1
go.drugbank.com/bio_entities/BE0003552TargetHumansReceptor to interleukin-8, which is a powerful neutrophils chemotactic factor (PubMed:1840701). Binding of IL-8 to the receptor causes activation of neutrophils.
Polypeptides: C-X-C chemokine receptor type 1Synonyms: IL-8 receptor type 1, High affinity interleukin-8 receptor AGamma-aminobutyric acid receptor subunit gamma-2
go.drugbank.com/bio_entities/BE0003592TargetHumansGABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity)
Polypeptides: Gamma-aminobutyric acid receptor subunit gamma-2Synonyms: GABA(A) receptor subunit gamma-2Gamma-aminobutyric acid receptor subunit rho-2
go.drugbank.com/bio_entities/BE0003598TargetHumansRho-2 GABAARs expressed in retina may play a role in retinal neurotransmission (By similarity) … Rho-2 GABAARs may contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission.
Polypeptides: Gamma-aminobutyric acid receptor subunit rho-2Synonyms: GABA(C) receptor, GABA(A) receptor subunit rho-2Acetylcholine receptor subunit beta-type unc-29
go.drugbank.com/bio_entities/BE0004928TargetCaenorhabditis elegansNon-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole.
Polypeptides: Acetylcholine receptor subunit beta-type unc-29Receptor-interacting serine/threonine-protein kinase 2
go.drugbank.com/bio_entities/BE0009532TargetHumansAlso involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696).
Polypeptides: Receptor-interacting serine/threonine-protein kinase 2Synonyms: Receptor-interacting protein 2Tyrosine-protein phosphatase non-receptor type 6
go.drugbank.com/bio_entities/BE0009941TargetHumansModulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). … Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788).
Polypeptides: Tyrosine-protein phosphatase non-receptor type 6Tumor necrosis factor receptor superfamily member 17
go.drugbank.com/bio_entities/BE0010010TargetHumansReceptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK
Polypeptides: Tumor necrosis factor receptor superfamily member 17Function: signaling receptor activity