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Displaying results 21 - 30 of 72 in total
  1. Target

    Carbonyl reductase [NADPH] 1

    go.drugbank.com/bio_entities/BE0003074
    TargetEnzymeHumans

    NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor...

    Synonyms: Alcohol dehydrogenase [NAD(P)+] CBR1
  2. Target

    Carbonyl reductases (CBRs)

    go.drugbank.com/bio_entities/BE0010129
    EnzymeHumans

    Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols (PubMed:18493841). Has low NADPH-dependent oxidoreductase activity.

    Synonyms: Alcohol dehydrogenase [NAD(P)+] CBR1
  3. Target

    Aldo-keto reductase family

    go.drugbank.com/bio_entities/BE0009802
    EnzymeHumans

    Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. … Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:10510318, PubMed:30538128).

    Synonyms: Alcohol dehydrogenase [NADP(+)]Function: alcohol dehydrogenase (NADP+) activity, alcohol dehydrogenase (NADP+) activity
  4. Target

    Aldo-keto reductase family 1 member B10

    go.drugbank.com/bio_entities/BE0004353
    TargetEnzymeHumans

    Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553

    Function: alcohol dehydrogenase (NADP+) activity
  5. Target

    Sorbitol dehydrogenase

    go.drugbank.com/bio_entities/BE0000299
    TargetEnzymeHumans

    Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. … Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor (PubMed:3365415)

  6. Target

    Aldo-keto reductase family 1 member C4

    go.drugbank.com/bio_entities/BE0000438
    TargetCarrierEnzymeHumans

    Catalyzes the biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol, leading to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity

  7. Target

    Aldehyde dehydrogenase family 1 member B1, mitochondrial

    go.drugbank.com/bio_entities/BE0000479
    TargetHumans

    Broad specificity, mitochondrial aldehyde dehydrogenase that could play a role in the detoxification of alcohol-derived acetaldehyde and other aldehydes (PubMed:20616185, PubMed:25413692, PubMed:35788181

  8. Target

    Dopamine receptor D3

    go.drugbank.com/bio_entities/BE0000581
    TargetHumans

    Involved in the incentive salience of drugs: controls responses to drug-related stimuli, making it a key target for reducing addiction to substances like cocaine, morphine, and alcohol (PubMed:10432116

  9. Target

    Sulfotransferase 2A1

    go.drugbank.com/bio_entities/BE0000886
    TargetEnzymeHumans

    Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional

  10. Target

    Lecithin retinol acyltransferase

    go.drugbank.com/bio_entities/BE0000900
    TargetEnzymeHumans

    It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase