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Displaying results 21 - 30 of 446 in total
  1. Target

    Disintegrin and metalloproteinase domain-containing protein 28

    go.drugbank.com/bio_entities/BE0003872
    TargetHumans

    May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L.

    Polypeptides: Disintegrin and metalloproteinase domain-containing protein 28Synonyms: Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L, Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II
  2. Target

    Sodium- and chloride-dependent GABA transporter 2

    go.drugbank.com/bio_entities/BE0004776
    TargetHumans

    Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:17502375, PubMed:22932902). Mediates transport of beta-alanine (PubMed:17502375). … Can also mediate transport of taurine and hypotaurine (By similarity)

    Polypeptides: Sodium- and chloride-dependent GABA transporter 2Function: amino acid transmembrane transporter activity
  3. Target

    Calcium and integrin-binding family member 2

    go.drugbank.com/bio_entities/BE0008698
    TargetHumans

    Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (By similarity). … Critical for proper photoreceptor cell maintenance and function (By similarity).

    Polypeptides: Calcium and integrin-binding family member 2
  4. Target

    Sodium- and chloride-dependent glycine transporter 1

    go.drugbank.com/bio_entities/BE0000940
    TransporterTargetHumans

    Sodium- and chloride-dependent glycine transporter (PubMed:37962965, PubMed:8183239). Essential for regulating glycine concentrations at inhibitory glycinergic synapses

    Polypeptides: Sodium- and chloride-dependent glycine transporter 1Function: amino acid
  5. Target

    Troponin C, slow skeletal and cardiac muscles

    go.drugbank.com/bio_entities/BE0001024
    TargetHumans

    Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.

    Polypeptides: Troponin C, slow skeletal and cardiac muscles
  6. Target

    Sodium- and chloride-dependent glycine transporter 2

    go.drugbank.com/bio_entities/BE0002310
    TransporterTargetHumans

    Sodium- and chloride-dependent glycine transporter (PubMed:10381548, PubMed:10606742, PubMed:16751771, PubMed:31370103, PubMed:9845349).

    Polypeptides: Sodium- and chloride-dependent glycine transporter 2
  7. Target

    Signal transducer and activator of transcription 3

    go.drugbank.com/bio_entities/BE0003462
    TargetHumans

    and IL6ST) (PubMed:9188471) … Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity

    Polypeptides: Signal transducer and activator of transcription 3
  8. Target

    Disintegrin and metalloproteinase domain-containing protein 17

    go.drugbank.com/bio_entities/BE0003754
    TargetHumans

    Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. … and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481, PubMed:38771644).

    Polypeptides: Disintegrin and metalloproteinase domain-containing protein 17
  9. Target

    Macrophage scavenger receptor types I and II

    go.drugbank.com/bio_entities/BE0010942
    TargetHumans

    Recognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation … Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands.

    Polypeptides: Macrophage scavenger receptor types I and IISynonyms: Macrophage acetylated LDL receptor I and II
  10. Target

    Cleavage and polyadenylation specificity factor subunit 3

    go.drugbank.com/bio_entities/BE0021153
    TargetHumans

    and other factors to bring about cleavage and poly(A) addition. … Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity)

    Polypeptides: Cleavage and polyadenylation specificity factor subunit 3Synonyms: Cleavage and polyadenylation specificity factor 73 kDa subunit