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Protein O-GlcNAcase
go.drugbank.com/bio_entities/BE0005827TargetHumansDeglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578). … Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:11148210, PubMed:11788610, PubMed:20673219, PubMed:22365600, PubMed:24088714, PubMed:28939839, PubMed:37962578).
Polypeptides: Protein O-GlcNAcaseSynonyms: Nuclear cytoplasmic O-GlcNAcase and acetyltransferaseSialate O-acetylesterase
go.drugbank.com/bio_entities/BE0019865EnzymeHumansCatalyzes the removal of O-acetyl ester groups from position 9 of the free diacetylated sialate N-acetyl-9-O-acetylneuraminate (Neu5,9Ac2) in the cytosol and of the diacetylated sialate residues of sialylglycoconjugates … Together with the sialate-O-acetyltransferase they regulate the balance of acetylated sialoglycoconjugates, key players in various processes such as cell-cell interactions, host-pathogen recognition, and
Polypeptides: Sialate O-acetylesteraseSynonyms: Sialic acid-specific 9-O-acetylesteraseMultidrug and toxin extrusion protein 2
go.drugbank.com/bio_entities/BE0004752TransporterHumansMediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. … Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney
Polypeptides: Multidrug and toxin extrusion protein 2Nucleolar and coiled-body phosphoprotein 1
go.drugbank.com/bio_entities/BE0005819TargetHumansIt has intrinsic GTPase and ATPase activities (PubMed:9016786) … processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
Polypeptides: Nucleolar and coiled-body phosphoprotein 1Cysteine and glycine-rich protein 1
go.drugbank.com/bio_entities/BE0009098TargetHumansCould play a role in neuronal development
Polypeptides: Cysteine and glycine-rich protein 1Sodium- and chloride-dependent taurine transporter
go.drugbank.com/bio_entities/BE0009148TransporterHumansTaurine acts as an anti-aging agent by reducing cellular senescence and combating oxidative stress: levels decline with age and supplementation has been shown to extend lifespan (By similarity). … Can also mediate transport of beta-alanine, hypotaurine and gamma-aminobutyric acid (GABA) (PubMed:39837997, PubMed:40108165, PubMed:40789850, PubMed:41269860, PubMed:8010975)
Polypeptides: Sodium- and chloride-dependent taurine transporterTRAF2 and NCK-interacting protein kinase
go.drugbank.com/bio_entities/BE0009399TargetHumansMAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed … Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development.
Polypeptides: TRAF2 and NCK-interacting protein kinaseDiacylglycerol O-acyltransferase 2
go.drugbank.com/bio_entities/BE0008719EnzymeTargetHumansEssential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. … Required for synthesis and storage of intracellular triglycerides (PubMed:27184406). Probably plays a central role in cytosolic lipid accumulation.
Polypeptides: Diacylglycerol O-acyltransferase 2Synonyms: Retinol O-fatty-acyltransferase, Acyl-CoA retinol O-fatty-acyltransferaseDiacylglycerol O-acyltransferase 1
go.drugbank.com/bio_entities/BE0012021TargetHumansCatalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:16214399, PubMed:18768481, PubMed:28420705, PubMed:32433610, … Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:16214399
Polypeptides: Diacylglycerol O-acyltransferase 1Synonyms: Retinol O-fatty-acyltransferase, Acyl-CoA retinol O-fatty-acyltransferaseSodium- and chloride-dependent GABA transporter 1
go.drugbank.com/bio_entities/BE0000249TargetHumans+), Cl(-) and GABA (By similarity). … The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(
Polypeptides: Sodium- and chloride-dependent GABA transporter 1