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Nicotinate and Nicotinamide Metabolism
smpdb.ca/view/SMP0000048MetabolicNicotinate (niacin) and nicotinamide - more commonly known as vitamin B3 - are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). NAD+ synthesis occurs either de ...
NAD+ Signalling and Aging
smpdb.ca/view/SMP0084271SignalingAn interesting link has emerged between NAD+ metabolism, SIRT1, SIRT3, and mitochondrial function. NR and PARP inhibitors increased life span in worms via activation of the mitochondrial unfolded protein response UPRmt by sir2.1. Short-t...
Vilanterol Action Pathway
smpdb.ca/view/SMP0126103Drug actionVilanterol is a long acting beta-2 adrenergic agonist. It can be found under the brand names Anoro, Anoro Ellipta, Breo Ellipta, and Trelegy Ellipta. It has a 24 hour activity and is used as a bronchodilator for the treatment of COPD and...
Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · VilanterolNAD+ Signalling Pathway (Cancer)
smpdb.ca/view/SMP0083297SignalingNAD+-dependent signalling pathways regulate many fundamental processes such as DNA repair, DNA transcription, cell proliferation, cell survival, cell cycle progression, apoptosis, and metabolism. These pathways are all linked to cancer d...