Hepatic Insufficiency (DBCOND0031307)

Identifiers

Synonyms
Hepatic insufficiency / Hepatic failure (disorder) / Hepatic failure, unspecified / Hepatic failure / Liver failure / Failure liver

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Nicotinamide
An ingredient found in a variety of cosmetic products.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05209295
A Study to Evaluate CC-486/Onureg in Participants With Moderate or Severe Hepatic Impairment Compared With Normal Hepatic Function in Participants With Myeloid Malignanciesbasic_science1recruiting
NCT05916560
A Study of LY3437943 in Participants With Impaired and Normal Liver Functionbasic_science1recruiting
NCT06575959
A Clinical Study of Enlicitide Decanoate in People With Liver Function Problems (MK-0616-030)No drug interventionstreatment1recruiting
NCT06390410
A Pharmacokinetic Study of Simufilam in Subjects with Impaired Hepatic Functionbasic_science1recruiting
NCT06620731
Clinical Trial of FCN-437c Capsule in Patients With Hepatic InsufficiencyNo drug interventionsother1completed
NCT02090621
Extracorporeal Photopheresis After Liver TransplantNo drug interventionstreatment2completed
NCT03341884
A Study of Ipatasertib in Participants With Mild, Moderate or Severe Hepatic Impairment Compared to Healthy Participantstreatment1completed
NCT04226833
A Study to Investigate the Effect of Impaired Hepatic Function on the Pharmacokinetics of Entrectinib in Volunteers With Different Levels of Hepatic Functiontreatment1completed
NCT03842761
A Study to Test How Different Doses of BI 685509 Are Tolerated in Patients With Liver ProblemsNo drug interventionstreatment1completed
NCT01512693
Assessment of Pharmacokinetics of Single Dose Odanacatib (MK-0822) in Participants With Moderate Hepatic Insufficiency (MK-0822-070)treatment1completed
NCT01186588
A Study of Canagliflozin in Study Participants With Various Degrees of Impaired Hepatic (Liver) FunctionNot Available1completed
NCT01836185
A Study of Evacetrapib (LY2484595) in Participants With Hepatic (Liver) Impairmentbasic_science1completed
NCT01019070
Hepatic Impaired Subjects Compared to Healthy Subjects Receiving Multi-dose BMS-650032Not Available1completed
NCT00969813
A Safety and Tolerability Study of CP-690,550 in Subjects With Hepatic Impairment and Normal Hepatic FunctionNot Available1completed
NCT01111318
Pharmacokinetics of Empagliflozin (BI 10773) in Patients With Impaired Liver Functiontreatment1completed
NCT00692341
Evaluation Of Hepatic Impairment On AG-013736 Pharmacokineticstreatment1completed
NCT02753517
Hepato Biliary Scintigraphy to Assess the Risk of Postoperative Liver Failure HepatectomiesNo drug interventionsscreeningNot Availableunknown_status
NCT00948558
Citrate Pharmacokinetics and Regional Citrate Anticoagulation in CRRTNo drug interventionsNot AvailableNot Availableunknown_status
NCT01043926
Pharmacokinetics of Suvorexant in Participants With Hepatic Insufficiency (MK-4305-017)treatment1completed
NCT01860326
Evaluate the Pharmacokinetics, Safety, and Tolerability of Alisporivir in Subjects With Hepatic Impairment Compared to Healthy SubjectsNot Available1completed
NCT02191865
Nintedanib in Volunteers With Hepatic Impairment Compared With Healthy Volunteerstreatment1completed
NCT02265627
Pharmacokinetics, Safety and Tolerability of BIIL 284 BS in Patients With Hepatic Impairment in Comparison to Healthy Volunteerstreatment1completed
NCT00968591
Pharmacokinetics of Everolimus in Subjects With Hepatic Insufficiencyother1completed
NCT02184091
Study to Evaluate the Effects of Underlying Renal or Hepatic Dysfunction on the Pharmacokinetics of Nevirapinetreatment1completed
NCT05440344
A Study of Imlunestrant (LY3484356) in Female Participants With Impaired Liver Functionbasic_science1completed
NCT03306667
Clinical Pharmacology of FYU-981 (Subjects With Hepatic Insufficiency)basic_science1completed
NCT04993404
Pharmacokinetics Of Jaktinib In Subjects With Hepatic Impairment And Normal Hepatic Functiontreatment1completed
NCT05093972
Ulonivirine (MK-8507) in Participants With Mild or Moderate Hepatic Impairment (MK-8507-014)treatment1not_yet_recruiting
NCT00509210
Study of Telaprevir in Subjects With Hepatic Impairmentbasic_science1completed
NCT02387814
A Study of Abemaciclib in Participants With Varying Degrees of Liver Impairmentbasic_science1completed
NCT01261923
Pharmacokinetics of 9-cis-retinoic Acid (Alitretinoin, Toctino®) in Patients With Hepatic DiseaseNot Available1 / 2completed
NCT00805090
Open-Label, Single-Dose Study to Evaluate the Safety and PK of DIC075V in Subjects With Renal Insufficiency and Hepatic Impairment Compared to Healthy Subjects and Evaluate the Safety and Pharmacokinetics of HPβCD When Administered in DIC075V Compared to Sporanox® in Healthy SubjectsNot Available1completed
NCT00645021
Study Examining The Effect Of Hepatic Impairment On Safety, Toleration And How The Body Processes An Experimental Drugtreatment1completed
NCT02800421
Prognostic Impact of Organ Damage in STEMI PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00416702
Safety and Pharmacokinetics of Indacaterol in Healthy Subjects and Those With Impaired Liver Functiontreatment1completed
NCT02457702
Mitochondrial Function in Patients With Severe Liver DiseaseNo drug interventionsbasic_scienceNot Availableterminated
NCT01043887
Ridaforolimus in Patients With Hepatic Insufficiency (MK-8669-046)treatment1completed
NCT00314054
Study Evaluating the Safety of HCV-796 in Subjects With Liver Disease and in Healthy Adultstreatment1completed
NCT00859053
Single-Dose Pharmacokinetics of BMS-790052 in Participants With Hepatic ImpairmentNot Available1completed
NCT01273493
A Pharmacokinetic Study of Trabectedin in Patients With Advanced Malignancies and Hepatic Dysfunctiontreatment1completed
NCT02170571
Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate in Patients With Moderate Hepatic Impairment Compared to Subjects With Normal Hepatic Functiontreatment1completed
NCT01870388
A Pharmacokinetic Study of Baricitinib in Participants With Liver Diseasebasic_science1completed
NCT04170309
Collection of Data of Ceftobiprole Treated Patients: Comparison of Patients With and Without Certain DiseasesNot AvailableNot Availablecompleted
NCT02894385
Effect of Hepatic and Renal Impairment on the Pharmacokinetics, Safety and Tolerability of BAY1841788 (ODM-201)other1completed
NCT00929032
Liver Transplantation and Reticuloendothelial Clearance CapacityNo drug interventionsNot AvailableNot Availablecompleted
NCT05882032
A Study of LY3502970 in Participants With Impaired and Normal Liver Functionbasic_science1recruiting
NCT02249442
Study to Determine the Pharmacokinetics on TPV/r in Subjects With Mild and Moderate Hepatic Insufficiencytreatment1completed
NCT03940742
A Study of Tirzepatide in Participants With Impaired Liver Functionbasic_science1completed
NCT01751399
A Single Dose Study of LY2605541 in Participants With Liver Impairmenttreatment1completed
NCT01797536
The Influence of Hepatic Insufficiency on the Pharmacokinetics of Elbasvir (MK-8742) (MK-8742-009)treatment1completed
NCT04147936
Study of the Safety and Tolerability of AXA1665 in Subjects With Mild and Moderate Hepatic InsufficiencyNo drug interventionsbasic_scienceNot Availablecompleted
NCT01475136
A Study of LY2140023 in Hepatically-Impaired Participantsbasic_science1completed
NCT04867941
A Study to Evaluate the Effect of Hepatic Insufficiency on the Pharmacokinetics (PK) of ACP-196treatment1completed
NCT02161224
A Study to Investigate the Exposure and Safety and Tolerability of a Single Dose of FG-4592 in Subjects With Moderately Diminished Liver Function Compared to Those With Normal Liver Functionbasic_science1completed
NCT06176716
Phase 1 Hepatic Insufficiency Trial of Methoxyethyl Etomidate HydrochlorideNo drug interventionsother1recruiting
NCT00781430
Study Evaluating The PK And Safety Of Neratinib In Healthy Subjects And Subjects With Chronic Liver DiseaseNot Available1completed
NCT00144248
A Pharmacokinetic Study to Assess Nevirapine [Viramune] Levels in HIV Infected Patients With Impaired Hepatic Functionstreatment4completed
NCT03968848
Investigate the Influence of Severe Hepatic Impairment on the Pharmacokinetics of Acalabrutinib and Its Metabolitetreatment1completed
NCT01891526
Single Dose of 9-cis-retinoic Acid in Hepatic PatientsNot AvailableNot Availablecompleted
NCT03295266
Single-Dose Pharmacokinetics of MK-3866 in Participants With Hepatic Impairment (MK-3866-006)No drug interventionstreatment1terminated
NCT02183376
Pharmacokinetics and Pharmacodynamics of BI 1356 in Subjects With Different Degrees of Liver Impairment as Compared to Healthy Subjectstreatment1completed
NCT00931060
Effects of Branched-Chain Amino Acids on Muscle Ammonia Metabolism in Patients With Cirrhosis and Healthy SubjectsNo drug interventionsNot AvailableNot Availablecompleted
NCT06190691
Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Liver Function and Healthy Participantsbasic_science1completed
NCT00623662
Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver ResectionNo drug interventionspreventionNot Availableunknown_status
NCT05661344
A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Liver Problemstreatment1completed
NCT04097704
Pharmacogenetics Sampling of the CC-90007-CP-003 Study CohortNo drug interventionsNot AvailableNot Availablecompleted
NCT05731895
A Study to Test How Iclepertin is Taken up in the Blood of People With and Without Liver Problemstreatment1completed
NCT02259855
Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hepatic Impairmenttreatment1completed
NCT02813538
Major Liver Resection: Early Clotting Disorders and Functional Impairment.Not AvailableNot Availablecompleted