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Sodium- and chloride-dependent GABA transporter 2
go.drugbank.com/bio_entities/BE0004776TargetHumansMediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:17502375, PubMed:22932902). Mediates transport of beta-alanine (PubMed:17502375). … Can also mediate transport of taurine and hypotaurine (By similarity)
Polypeptides: Sodium- and chloride-dependent GABA transporter 2Function: amino acid transmembrane transporter activityCalcium and integrin-binding family member 2
go.drugbank.com/bio_entities/BE0008698TargetHumansRequired for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (By similarity). … Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair
Polypeptides: Calcium and integrin-binding family member 2Sodium- and chloride-dependent glycine transporter 1
go.drugbank.com/bio_entities/BE0000940TransporterTargetHumansSodium- and chloride-dependent glycine transporter (PubMed:37962965, PubMed:8183239). Essential for regulating glycine concentrations at inhibitory glycinergic synapses
Polypeptides: Sodium- and chloride-dependent glycine transporter 1Function: amino acidTroponin C, slow skeletal and cardiac muscles
go.drugbank.com/bio_entities/BE0001024TargetHumansTn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.
Polypeptides: Troponin C, slow skeletal and cardiac musclesSodium- and chloride-dependent glycine transporter 2
go.drugbank.com/bio_entities/BE0002310TransporterTargetHumansSodium- and chloride-dependent glycine transporter (PubMed:10381548, PubMed:10606742, PubMed:16751771, PubMed:31370103, PubMed:9845349).
Polypeptides: Sodium- and chloride-dependent glycine transporter 2Signal transducer and activator of transcription 3
go.drugbank.com/bio_entities/BE0003462TargetHumansActs as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell … and IL6ST) (PubMed:9188471)
Polypeptides: Signal transducer and activator of transcription 3Disintegrin and metalloproteinase domain-containing protein 17
go.drugbank.com/bio_entities/BE0003754TargetHumansMediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. … and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481, PubMed:38771644).
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 17Macrophage scavenger receptor types I and II
go.drugbank.com/bio_entities/BE0010942TargetHumansRecognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation … Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands.
Polypeptides: Macrophage scavenger receptor types I and IISynonyms: Macrophage acetylated LDL receptor I and IICleavage and polyadenylation specificity factor subunit 3
go.drugbank.com/bio_entities/BE0021153TargetHumansand other factors to bring about cleavage and poly(A) addition. … Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity)
Polypeptides: Cleavage and polyadenylation specificity factor subunit 3Synonyms: Cleavage and polyadenylation specificity factor 73 kDa subunitMultifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
go.drugbank.com/bio_entities/BE0002195TargetEnzymeHumansCatalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:25419660). … Essential for normal biosynthesis and secretion of type IV collagens (Probable) (PubMed:18834968). Essential for normal formation of basement membranes (By similarity)
Polypeptides: Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3