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Thiethylperazine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126477Drug actionThiethylperazine is in the class of the piperazine - phenothiazines which are a class of first generation antipsychotic medications. Phenothiazines are generally dopamine receptor antagonists. Thiethylperazine' s antipsychotic effect is ...
Lurasidone Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126527Drug actionLurasidone is is a benzothiazol derivative and an atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Lurasidone is an atypical antipsychotic that is a D2 and 5-HT2A (mixed serot...
Amisulpride Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126531Drug actionAmisulpride, a substituted benzamide derivative, is a second-generation (atypical) antipsychotic. Amisulpride is a selective dopamine D2 and D3 receptor antagonist with no affinity towards other dopamine receptor subtypes. At low doses, ...
Triflupromazine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126551Drug actionTriflupromazine is a member of a class of drugs called phenothiazines, which are dopamine D1/D2 receptor antagonists. Triflupromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can a...
Tiapride Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126581Drug actionTiapride is a selective D2 and D3 dopamine receptor blocker indicated for the treatment of a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitati...
Acepromazine - Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126586Drug actionAcepromazine is a phenothiazine tranquilizer that blocks dopamine receptors in the CNS and depresses the reticular-activating system, resulting in sedation. Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It...
Chlorprothixene Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126587Drug actionChlorprothixene is a thioxanthene antipsychotic. Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the ...
Brexpiprazole Serotonin Action Action Pathway
smpdb.ca/view/SMP0126699Drug actionAlthough the exact mechanism of action of brexpiprazole in psychiatric disorders has not been fully elucidated, the efficacy of brexpiprazole may be attributed to combined partial agonist activity at 5-HT1A and dopamine D2 receptors, and...
Ondansetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126768Drug actionOndansetron acts both centrally and peripherally to prevent and treat nausea and vomiting. Central effects are mediated by the antagonism of 5HT-3 serotonin receptors in the area postrema. The area postrema, located on the fourth ventric...
Dolasetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126782Drug actionDolasetron is a selective serotonin 5-HT3 receptor antagonist. In vivo, the drug is rapidly converted into its major active metabolite, hydrodolasetron, which seems to be largely responsible for the drug's pharmacological activity. The a...