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NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
go.drugbank.com/bio_entities/BE0000089TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The ...
Polypeptides: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
go.drugbank.com/bio_entities/BE0000244TargetHumansIrreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate.
Polypeptides: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrialcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
go.drugbank.com/bio_entities/BE0000436TargetHumansCyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has ...
Polypeptides: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3AFunction: 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activityBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
go.drugbank.com/bio_entities/BE0003094TargetHumansThe first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate
Polypeptides: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1POU domain, class 5, transcription factor 1
go.drugbank.com/bio_entities/BE0003665TransporterTargetHumansTranscription factor that binds to the octamer motif (5'-ATTTGCAT-3').
Polypeptides: POU domain, class 5, transcription factor 12,3-diketo-5-methylthiopentyl-1-phosphate enolase
go.drugbank.com/bio_entities/BE0003741TargetGeobacillus kaustophilus (strain HTA426)Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P).
Polypeptides: 2,3-diketo-5-methylthiopentyl-1-phosphate enolaseFunction: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activityType II inositol 1,4,5-trisphosphate 5-phosphatase
go.drugbank.com/bio_entities/BE0004437TargetHumansAlso hydrolyzes the 5-position phosphate from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), thereby modulating cellular signaling events … Regulates phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) cellular levels by cleaving the phosphate at the 5-position producing PtdIns(4)P.
Polypeptides: Type II inositol 1,4,5-trisphosphate 5-phosphataseSynonyms: Phosphoinositide 5-phosphatase, 75 kDa inositol polyphosphate-5-phosphataseInsulin-like growth factor-binding protein 5
go.drugbank.com/bio_entities/BE0009661CarrierHumansMultifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type spe...
Polypeptides: Insulin-like growth factor-binding protein 5Synonyms: IBP-5, IGFBP-5Sodium channel protein type 5 subunit alpha
go.drugbank.com/bio_entities/BE0000197TargetHumansPore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (PubMed:33712541, PubMed:40768348). Navs, also called VGSCs (voltage-gated sod...
Polypeptides: Sodium channel protein type 5 subunit alphaTumor necrosis factor receptor superfamily member 5
go.drugbank.com/bio_entities/BE0001196TargetHumansReceptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)
Polypeptides: Tumor necrosis factor receptor superfamily member 5