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Plazomicin
go.drugbank.com/drugs/DB12615ApprovedIt mediates the antibacterial activity by binding to bacterial 30S ribosomal subunit and inhibiting protein synthesis [FDA Label]. … It is marketed as Zemdri and is administered via once-daily intravenous infusion.
Human cytomegalovirus immune globulin
go.drugbank.com/drugs/DB13886ApprovedInvestigationalDuring the span of an individual's life, the virus may reactivate, resulting in repeated shedding and spread of the virus. … CMV infection can lead to a high fever and severe organ-specific damage with significant morbidity and mortality rates.
Categories: Amino Acids, Peptides, and Proteins, Immune Sera and ImmunoglobulinsProducts: MEGALOTECT CP SOLUTION FOR INFUSION 100 U/MLOxilofrine
go.drugbank.com/drugs/DB11610ApprovedOxilofrine is used in combination with [DB11609] as an antitussive. It is currently marketed in Canada by Valeant under the tradename Cophylac.
Apraclonidine
go.drugbank.com/drugs/DB00964ApprovedInvestigationalApraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
Categories: Antiglaucoma Preparations and Miotics, Sympathomimetics in Glaucoma TherapyObiltoxaximab
go.drugbank.com/drugs/DB05336ApprovedObiltoxaximab, an affinity-enhanced monoclonal antibody (Mab), is used for prevention and treatment of infection and death caused by anthrax toxin. … Obiltoxaximab is a chimeric IgG1 kappa monoclonal antibody (mAb) that binds the PA component of B. anthracis toxin. It has an approximate molecular weight of 148 kDa.
Categories: Amino Acids, Peptides, and Proteins, Immune Sera and ImmunoglobulinsEtranacogene dezaparvovec
go.drugbank.com/drugs/DB16791ApprovedInvestigational[L45255] Etranacogene dezaparvovec was approved by the EMA in February 2023[L45439,L45444] and by Health Canada in October 2023.[L48801] … Hemophilia B - also called factor IX deficiency or Christmas disease - is an X-linked genetic disorder resulting in an absence or deficiency of clotting factor IX.
Categories: Cellular and Gene Therapy, Blood and Blood Forming OrgansAlpha-2-macroglobulin
go.drugbank.com/bio_entities/BE0000910TargetCarrierHumansFollowing cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase … When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase.
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
go.drugbank.com/bio_entities/BE0000931TargetHumansHas ADP-ribosyltransferase activity toward GLP1R
Synonyms: ADP-ribosyltransferase C2 and C3 toxin-like 1Respiratory Infection
go.drugbank.com/conditions/DBCOND0034122Synonyms: Recurrent Upper and Lower Respiratory Tract Infections (RTIs)Tiopronin
go.drugbank.com/drugs/DB06823ApprovedIt is similar to d-penicillamine in use and efficacy, but offers the advantage of far less adverse effects. … As cystinuria is a relatively rare disease, tiopronin is classified as an orphan drug and is not patented in the United States.
Categories: Reducing and Complexing Thiol, Amino Acids, Peptides, and Proteins