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Tromethamine
go.drugbank.com/drugs/DB03754ApprovedInvestigationalIt is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used … as an alkalizer.
Categories: Compounds used in a research, industrial, or household setting, Blood and Blood Forming OrgansNusinersen
go.drugbank.com/drugs/DB13161ApprovedInvestigationalAn antisense oligonucleotide that induces survival motor neuron (SMN) protein expression, it was approved by the U.S. … FDA in December, 2016 as Spinraza for the treatment of children and adults with spinal muscular atrophy (SMA). It is adminstrated as direct intrathecal injection.
Categories: Nucleic Acids, Nucleotides, and NucleosidesCocaine
go.drugbank.com/drugs/DB00907ApprovedIllicitInvestigationalIt is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. … An alkaloid ester extracted from the leaves of plants including coca.
Categories: Analgesics and AnestheticsProducts: Cocaine Hydrochloride Top Sol 40mg/mlArticaine
go.drugbank.com/drugs/DB09009ApprovedInvestigationalArticaine is a dental local anesthetic. Articaine is widely used around the world and is the most popular local anesthetic in many European countries.
Mixtures: Articaine Hydrochloride and Epinephrine Injection - N, Ultracaine DS InjSymptomatic Epilepsy
go.drugbank.com/conditions/DBCOND0119818Synonyms: Epilepsy and recurrent seizuresAcoramidis
go.drugbank.com/drugs/DB17999ApprovedInvestigational[A264808] It was brought to market by BridgeBio Pharma and approved by the FDA in November 2024 to reduce negative cardiovascular outcomes in patients with cardiomyopathy caused by TTR amyloidosis. … [L51958] Similar to the previously developed [tafamidis], acoramidis is used to stabilize TTR in its tetrameric form, preventing the formation of amyloidogenic monomers and the progression of amyloidosis
Levonordefrin
go.drugbank.com/drugs/DB06707ApprovedInvestigationalLevonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry.
Mixtures: Mepivacaine Hydrochloride and Levonordefrin, Isocaine HCl Inj 2%Categories: Epinephrine and similarsLasofoxifene
go.drugbank.com/drugs/DB06202ApprovedInvestigationalWithdrawnIt was initially developed as Oporia by Pfizer as a treatment for postmenopausal osteoporosis and vaginal atrophy, in which were both rejected for approval by FDA. … It gained approval by European Commission in March 2009.
Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System