Levonordefrin is a topical sympathomimetic amine found in local anesthetic products that is used for nasal decongestion or vasoconstriction during dental procedures. Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry.
- Mechanism
- Curator reviewed
It is designed to mimic the molecular shape of adrenaline. It binds to alpha-adrenergic receptors in the nasal mucosa. Here it can, therefore, cause vasoconstriction.
- Primary indication
- Used as a topical nasal decongestant and vasoconstrictor in dentistry.Curator reviewed · 3 structured indications
- Formula / weight
- C9H13NO3 · 183.2044 g/mol (avg)
- First approval
- Canada, 2002 · United States, 1984
- Also known as
- alpha-Methylnoradrenaline · Corbadrine · L-Nordefrin · Neo-cobefrin
- Code names
- BA-2818
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
GEFQWZLICWMTKF-CDUCUWFYSA-NSMILESC[C@H](N)[C@H](O)C1=CC(O)=C(O)C=C1What you can answer from here — as of September 08, 2026
4Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Levonordefrin, and which of those have an active Phase 3 trial?
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