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3',5'-cyclic-AMP phosphodiesterase 4B
go.drugbank.com/bio_entities/BE0000487TargetHumansHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to...
Polypeptides: 3',5'-cyclic-AMP phosphodiesterase 4BFunction: 3',5'-cyclic-AMP phosphodiesterase activityDelta-1-pyrroline-5-carboxylate synthase
go.drugbank.com/bio_entities/BE0000823TargetHumansBifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine
Polypeptides: Delta-1-pyrroline-5-carboxylate synthase5-aminolevulinate synthase, erythroid-specific, mitochondrial
go.drugbank.com/bio_entities/BE0000898TargetHumansCatalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:14643893, PubMed:21252495, PubMed
Polypeptides: 5-aminolevulinate synthase, erythroid-specific, mitochondrialSynonyms: 5-aminolevulinic acid synthase 23',5'-cyclic-AMP phosphodiesterase 4A
go.drugbank.com/bio_entities/BE0001133TargetHumansHydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes
Polypeptides: 3',5'-cyclic-AMP phosphodiesterase 4AFunction: 3',5'-cyclic-AMP phosphodiesterase activity3',5'-cyclic-AMP phosphodiesterase 4C
go.drugbank.com/bio_entities/BE0002353TargetHumansHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes
Polypeptides: 3',5'-cyclic-AMP phosphodiesterase 4CFunction: 3',5'-cyclic-AMP phosphodiesterase activityBaculoviral IAP repeat-containing protein 5
go.drugbank.com/bio_entities/BE0003408TargetHumansMultitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:20627126, PubMed:21364656, PubMed:25778398, PubMed:28218735, PubMed:9859993). Component of a chromosome passage protein complex (CP...
Polypeptides: Baculoviral IAP repeat-containing protein 5Serine/threonine-protein kinase PAK 5
go.drugbank.com/bio_entities/BE0009510TargetHumansSerine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor rec...
Polypeptides: Serine/threonine-protein kinase PAK 5Synonyms: PAK-5, p21-activated kinase 5Belatacept
go.drugbank.com/drugs/DB06681ApprovedInvestigationalStructurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it is a homodimer of two homologous polypeptide chains of 357 amino acids each. … Belatacept is only 2 amino acids different from abatacept (Orencia). FDA approved on June 15, 2011.
Categories: Selective T Cell Costimulation Blocker, T Lymphocyte Costimulation Activity BlockadeProducts: NULOJIX ®250 MG/ VIAL POLVO LIOFILIZADO PARA SOLUCION INYECTABLE INTRAVENOSADisulfiram
go.drugbank.com/drugs/DB00822ApprovedInvestigationalA carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. … It acts by inhibiting aldehyde dehydrogenase.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: N,N,N',N'-tetraethylthiuram disulfide, 1,1'-dithiobis(N,N-diethylthioformamide)Encorafenib
go.drugbank.com/drugs/DB11718ApprovedInvestigationalEncorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. … [L12216] This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and secretion.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: BRAFTOVI® 75 MG CÁPSULAS, BRAFTOVİ 75 MG SERT KAPSÜL, 42 ADET